Abstract

Two new phenolic glycosides, oroxylumosides A (1) and B (2), along with four known compounds darendoside A (3), leucosceptoside A (4), acteoside (5) and decaffeoylacteoside (6) were isolated from the stem bark of Oroxylum indicum. Their structures were elucidated by extensive analysis of the 1 D and 2 D NMR as well as HR-ESI-QTOF-MS. In addition, compounds 1 − 4 exhibited inhibitory effects on NO production in LPS-stimulated BV2 microglial cell line with IC₅₀ values of 58.2 ± 2.9, 70.6 ± 3.5, 56.8 ± 2.8 and 61.1 ± 3.1 µM, respectively.

摘要

两种新的酚苷，oroxylumoside A ( 1 ) 和 B ( 2 )，以及四种已知化合物darendoside A ( 3 )、leucosceptoside A ( 4 )、acteoside ( 5 ) 和decaffeoylacteoside ( 6 ) 从Oroxylum的茎皮中分离出来指标。通过对 1 D 和 2 D NMR 以及 HR-ESI-QTOF-MS 的广泛分析阐明了它们的结构。此外，化合物1-4对 LPS 刺激的 BV2 小胶质细胞系中的 NO 产生具有抑制作用，IC _{50值分别为 58.2 ±}  2.9、70.6 ± 3.5、56.8 ± 2.8 和 61.1 ± 3.1 µM。