Hypochlorite (ClO⁻) is of great importance either for the metabolism of living organisms or as disinfectant in daily life. However, improper concentration levels of ClO⁻ lead to serious health problems including erythrocyte damage, cardiovascular problems, neuron degeneration, lung/kidney injury, and cancer. Therefore, a sensitive and selective detection method is required for the visualization and measurement of ClO⁻. In this work, a novel platinum(II) complex-based luminescent probe Pt-CHO was synthesized and utilized to detect ClO⁻. This "turn off" probe exhibits high sensitivity, excellent selectivity, good pH stability, low limit of detection, and instantaneous response ability. Moreover, the luminescent response is caused by the oxidation of aldehyde into carboxyl groups combined with the coordination of hydroxyl groups at the Pt center, which is rarely reported. The cell imaging of HeLa cells proved the considerable potential of the probe for ClO⁻ imaging in living cells.

中文翻译：

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用于检测癌细胞中次氯酸盐的新型铂 (II) 络合物发光探针

次氯酸盐 (ClO⁻) 对生物体的新陈代谢或日常生活中的消毒剂都非常重要。然而，不适当的 ClO⁻ 浓度会导致严重的健康问题，包括红细胞损伤、心血管问题、神经元变性、肺/肾损伤和癌症。因此，需要一种灵敏且选择性的检测方法来实现 ClO⁻ 的可视化和测量。在这项工作中，合成了一种新型的基于铂 (II) 配合物的发光探针 Pt-CHO，并用于检测 ClO⁻。这种“关闭”探针具有高灵敏度、出色的选择性、良好的 pH 稳定性、低检测限和瞬时响应能力。而且，发光反应是由醛氧化成羧基与Pt中心羟基的配位结合引起的，很少报道。HeLa 细胞的细胞成像证明了探针在活细胞中进行 ClO⁻ 成像的巨大潜力。