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Molecularly Imprinted Polymer‐Based Smart Prodrug Delivery System for Specific Targeting, Prolonged Retention, and Tumor Microenvironment‐Triggered Release
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2020-10-19 , DOI: 10.1002/anie.202012956
Zikuan Gu 1 , Yueru Dong 1 , Shuxin Xu 1 , Lisheng Wang 2 , Zhen Liu 1
Affiliation  

Prodrug and drug delivery systems are two effective strategies for improving the selectivity of chemotherapeutics. Molecularly imprinted polymers (MIPs) have emerged as promising carriers in targeted drug delivery for cancer treatment, but they have not yet been integrated with the prodrug strategy. Reported here is an MIP‐based smart prodrug delivery system for specific targeting, prolonged retention time, and tumor microenvironment‐triggered release. 5′‐Deoxy‐5‐fluorocytidine (DFCR) and sialic acid (SA) were used as a prodrug and a marker for tumor targeting, respectively. Their co‐imprinted nanoparticles were prepared as a smart carrier. Prodrug‐loaded MIP specifically and sustainably accumulated at the tumor site and then gradually released. Unlike conventional prodrug designs, which often require in‐liver bioconversion, this MIP‐based prodrug delivery is liver‐independent but tumor‐dependent. Thus, this study opens new access to the development of smart prodrug delivery nanoplatforms.

中文翻译:

分子印迹聚合物为基础的智能前药递送系统,可实现特异性靶向,长期保留和肿瘤微环境触发释放

前药和药物输送系统是提高化学疗法选择性的两种有效策略。分子印迹聚合物(MIP)在靶向治疗癌症的药物输送中已成为有希望的载体,但尚未与前药策略整合。此处报告的是基于MIP的智能前药输送系统,可实现特定的靶向,延长的保留时间以及肿瘤微环境触发的释放。5'-脱氧-5-氟胞苷(DFCR)和唾液酸(SA)分别用作前药和肿瘤靶向标记。他们的共印纳米颗粒被制备为智能载体。载有前药的MIP特别且可持续地积聚在肿瘤部位,然后逐渐释放。与常规前药设计不同,后者通常需要进行体内生物转化,这种基于MIP的前药递送不依赖肝脏,但依赖肿瘤。因此,这项研究为开发智能前药输送纳米平台开辟了新途径。
更新日期:2020-10-19
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