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Phytochemicals, antioxidant and anti-proliferative activities of Myrtus communis L. genotypes from Tunisia
South African Journal of Botany ( IF 3.1 ) Pub Date : 2021-03-01 , DOI: 10.1016/j.sajb.2020.09.040
Islem Yangui , Faten Younsi , Wafa Ghali , Mohamed Boussaid , Chokri Messaoud

Abstract Myrtle (Myrtus communis L.) has long been regarded as a medicinal and aromatic plant. The analysis of phenolic and terpenic compounds contained in the leaf extracts of three Myrtle genotypes showed their richness in monoterpene hydrocarbons (48, 32%, 83.77%), flavonols, and hydrolysable tannins. Phenolic profiles and volatile compounds varied significantly among genotypes. All leaves extracts revealed excellent DPPH scavenging activity and β-carotene bleaching inhibition capacity (IC50=3.81 µg/ml, IC50= 3.58 µg/ml, respectively). The MTT metabolism assay demonstrated the efficacy of M. communis genotypes against PC12 cancer cell proliferation and their safety towards normal cells. Caspases 3/7 induction, apoptosis and intracellular ROS accumulation of treated cancer cell lines proved the cytotoxic effect of M. communis genotypes. This cytotoxic activity could be related to the antioxidant properties of the studied extracts. Antioxidant and antiproliferative activities varied significantly among genotypes. Such variation is attributed to chemical composition differences. Our results highlighted the interest of use of M. communis extracts as an industrial crop or as an ingredient in functional foods.

中文翻译:

突尼斯桃金娘基因型的植物化学物质、抗氧化和抗增殖活性

摘要 桃金娘 (Myrtus community L.) 长期以来被认为是一种药用和芳香植物。对三种桃金娘基因型叶提取物中酚类和萜类化合物的分析表明,它们富含单萜烃(48、32%、83.77%)、黄酮醇和可水解单宁。基因型之间的酚类特征和挥发性化合物差异很大。所有叶子提取物均显示出优异的 DPPH 清除活性和 β-胡萝卜素漂白抑制能力(分别为 IC50=3.81 µg/ml,IC50=3.58 µg/ml)。MTT 代谢测定证明了 M.communis 基因型对 PC12 癌细胞增殖的功效及其对正常细胞的安全性。经处理的癌细胞系的半胱天冬酶 3/7 诱导、细胞凋亡和细胞内 ROS 积累证明了 M.communis 基因型的细胞毒性作用。这种细胞毒活性可能与所研究提取物的抗氧化特性有关。抗氧化和抗增殖活性在基因型之间差异很大。这种变化归因于化学成分的差异。我们的研究结果突出了使用 M.communis 提取物作为经济作物或作为功能性食品成分的兴趣。
更新日期:2021-03-01
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