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Decreased investigatory head scanning during exploration in learning-impaired, aged rats
Neurobiology of Aging ( IF 4.2 ) Pub Date : 2021-02-01 , DOI: 10.1016/j.neurobiolaging.2020.10.008
Geeta Rao 1 , Heekyung Lee 1 , Michela Gallagher 2 , James J Knierim 3
Affiliation  

"Head scanning" is an investigatory behavior that has been linked to spatial exploration and the one-trial formation or strengthening of place cells in the hippocampus. Previous studies have demonstrated that a subset of aged rats with normal spatial learning performance show head scanning rates during a novel, local-global cue-mismatch manipulation that are similar to those of young rats. However, these aged rats demonstrated different patterns of expression of neural activity markers in brain regions associated with spatial learning, perhaps suggesting neural mechanisms that compensate for age-related brain changes. These prior studies did not investigate the head scanning properties of aged rats that had spatial learning impairments. The present study analyzed head scanning behavior in young, aged-unimpaired, and aged-impaired Long Evans rats. Aged-impaired rats performed the head scan behavior at a lower rate than the young rats. These results suggest that decreased attention to spatial landmarks may be a contributing factor to the spatial learning deficits shown by the aged-impaired rats.

中文翻译:

在学习受损的老年大鼠探索期间减少调查性头部扫描

“头部扫描”是一种调查行为,与空间探索和海马中位置细胞的单次试验形成或加强有关。先前的研究表明,具有正常空间学习能力的老年大鼠子集在一种新颖的局部-全局提示不匹配操作期间显示出与年轻大鼠相似的头部扫描率。然而,这些老年大鼠在与空间学习相关的大脑区域中表现出不同的神经活动标记表达模式,这可能表明了补偿与年龄相关的大脑变化的神经机制。这些先前的研究没有调查有空间学习障碍的老年大鼠的头部扫描特性。本研究分析了年轻、年老体弱者的头部扫描行为,和老年受损的 Long Evans 大鼠。老年大鼠进行头部扫描行为的频率低于年轻大鼠。这些结果表明,对空间地标的关注减少可能是老年受损大鼠表现出的空间学习缺陷的一个促成因素。
更新日期:2021-02-01
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