当前位置: X-MOL 学术Environ. Toxicol. Pharmacol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Gender differences in UV-induced skin inflammation, skin carcinogenesis and systemic damage
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-10-20 , DOI: 10.1016/j.etap.2020.103512
Qing-Yuan Zhong , Bing Lin , Yin-Ting Chen , Yin-Ping Huang , Wei-Peng Feng , Ying Wu , Gui-Hong Long , Yun-Nan Zou , Yu Liu , Bao-Qin Lin , Nian-Li Sang , Janis Ya-Xian Zhan

Ultraviolet (UV) radiation-induced chronic inflammation contributes to all stages of skin tumor development. In addition, gender plays an important role in inflammatory diseases or cancer. In this study, histopathology changes, hematology, oxidative stress and inflammatory response were used to evaluate sex differences in UV-induced chronic inflammation-associated cancer development. The results showed that the male and female mice had photoaging damage at the 9th week. However, skin tumors only appeared in male mice at 31st week. Furthermore, UV increased ROS production, p65, p-p65, IL-6 and TNF-α protein expressions in skin, and these factors elevated more in male mouse model. Hematology results showed that the parameters of blood systemic inflammation were changed in different degrees in model groups, while the pathological results showed inflammatory cell infiltration in the internal organs of both model groups in varying degrees. These results indicate that there are gender differences in UV-induced skin inflammation, carcinogenesis and systemic damage. Moreover, male mice are more sensitive to UV irradiation, which may be responsible to greater oxidative stress and inflammatory damage.



中文翻译:

紫外线引起的皮肤炎症,皮肤致癌作用和全身性损伤的性别差异

紫外线(UV)引起的慢性炎症有助于皮肤肿瘤发展的所有阶段。此外,性别在炎症性疾病或癌症中也起着重要作用。在这项研究中,使用组织病理学变化,血液学,氧化应激和炎症反应来评估紫外线诱发的慢性炎症相关癌症发展过程中的性别差异。结果表明,雄性和雌性小鼠在第9周有光老化损伤。但是,皮肤肿瘤仅在第31周出现在雄性小鼠中。此外,紫外线会增加皮肤中的ROS产生,p65,p-p65,IL-6和TNF-α蛋白表达,而这些因素在雄性小鼠模型中会进一步升高。血液学结果表明,模型组血液系统炎症参数有不同程度的改变,病理结果显示模型组内脏炎症细胞均有不同程度的浸润。这些结果表明,紫外线引起的皮肤炎症,致癌作用和全身性损伤存在性别差异。此外,雄性小鼠对紫外线辐射更敏感,紫外线辐射可能是造成更大的氧化应激和炎症损害的原因。

更新日期:2020-10-30
down
wechat
bug