Abstract

A phytochemical investigation of the EtOH extract of the flowers of Lagerstroemia indica L. led to the isolation and characterization of a new pyrrole alkaloid, named lagerindicine (1), along with four known compounds (2–5). Their structures were elucidated by the detailed spectroscopic analysis and comparison with literature data, whereas the structure, in particularly, the absolute configuration (AC) of 1, was firmly determined by total synthesis. All the isolates were evaluated for their cytotoxic effects against human colon cancer cell (HCT-116), and compound 3 exhibited weak cytotoxicity with IC₅₀ value of 28.4 μM.

Graphic Abstract

中文翻译：

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Lagerindicine，一种新的从紫薇花中分离出来的吡咯类生物碱

摘要

的花的乙醇提取物的植物化学研究紫薇L.导致分离和一个新的吡咯生物碱的表征，命名lagerindicine（1），具有四个已知化合物（沿2 - 5）。其结构经详细的光谱分析和与文献数据的比较阐明，而结构，具体地，绝对构型的（AC）1，牢固地通过全合成来确定。评价所有分离物对人结肠癌细胞（HCT-116）的细胞毒性作用，化合物3表现出弱的细胞毒性，IC ₅₀值为28.4μM。

图形摘要