Abstract

An integrated microscopic study of the destruction of mouse Ehrlich ascites carcinoma (EAC) cells under starvation conditions has been carried out. It has been found that, in addition to apoptosis, necrosis, and apoptotic necrosis, already known for EAC, cell destruction can also occur through mitochondrial autolysis, which is proposed to be considered a new kind of mitoptosis. A mitoptosis in EAC is characterized by the appearance of many autolyzing mitochondria, the fusion of which leads to rupture of the cell membrane and the ejection of the nucleus from the cell. It is assumed that the polymorphism of EAC destruction patterns is explained by the different physiological state of the cells, which determines the “choice” of the cell death mechanism. This situation poses a challenge for researchers to develop complex inducers with the ability to stimulate all possible types of cancer cell death.

中文翻译：

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在埃里希氏癌细胞中发现异常的线粒体途径

摘要

进行了在饥饿条件下破坏小鼠艾氏腹水癌（EAC）细胞的综合显微镜研究。已经发现，除了已经为EAC所知的凋亡，坏死和凋亡坏死之外，还可以通过线粒体自溶作用发生细胞破坏，这被认为是一种新的有丝分裂。EAC中的有丝分裂现象的特征是出现了许多自溶的线粒体，线粒体的融合导致细胞膜破裂和细胞核从细胞中弹出。假定EAC破坏模式的多态性是由细胞的不同生理状态解释的，这决定了细胞死亡机制的“选择”。