Abstract

The present study demonstrates the effect of combined ionizing radiation (γ rays, 0.24 Gy, 661.7 keV, whole body and ¹²C, 0.18 Gy, 450 MeV, head region) on the behavior of animals in mouse transgenic models of Alzheimer’s disease. Significant improvement of spatial learning and stimulation of locomotor and exploratory behavior were observed in wild-type mice after irradiation. However, an anxiolytic effect and stimulation of locomotor and exploratory behavior were revealed in irradiated mice with tauopathy. Mice with cerebral amyloidosis also exhibited improved learning in the odor recognition test. No negative effects of irradiation were detected.

中文翻译：

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电离辐射对阿尔茨海默氏病小鼠模型认知功能的影响

摘要

本研究证明了组合电离辐射（γ射线，0.24 Gy，661.7 keV，全身和¹² C，0.18 Gy，450 MeV，头部区域）对小鼠阿尔茨海默氏病转基因模型中动物行为的影响。在照射后，在野生型小鼠中观察到空间学习的显着改善以及对运动和探索行为的刺激。然而，在经放射治疗的具有tauopathy的小鼠中发现了抗焦虑作用以及对运动和探索行为的刺激。患有脑淀粉样变性的小鼠在气味识别测试中也表现出更好的学习。没有检测到辐射的负面影响。