Background

Multiple sclerosis (MS) is a complex autoimmune disorder characterized by neurologic dysfunction. The symptoms worsen as the disease progresses to the relapsing stage.

Aim

This study aimed to examine the role of T cells in MS pathogenesis.

Materials and methods

The review was performed based on articles obtained from PsycINFO, PubMed, Web of Science, and CINAHL. Search terms and phrases, such as “multiple sclerosis,” “MS,” “T cells,” “development,” “Dysregulated T cells,” and “Effector T cells”, were used to identify articles that could help explore the research topic.

Results

The pathogenesis of MS is linked to the regulatory, inflammatory, suppressive, and effector roles of T cells. However, the actual roles of specific T cell subsets in MS development are not well understood.

Discussion

The study revealed a significant link between MS and T cell activity. Targeting T cells is a potential strategy for the development of new therapies to manage MS.

Conclusion

MS is a complex demyelinating condition that affects several million people around the world. Research has revealed that various classes of T cells, including effector T cells and regulatory T cells, influence the development and progression of MS. Further investigations are required to elucidate the underlying mechanisms through which specific T cell populations influence MS pathogenesis.

中文翻译：

---

T 细胞在多发性硬化症中的作用：我们目前知道什么？

背景

多发性硬化症 (MS) 是一种以神经功能障碍为特征的复杂自身免疫性疾病。随着疾病进展到复发阶段，症状会恶化。

目标

本研究旨在探讨 T 细胞在 MS 发病机制中的作用。

材料和方法

审查是根据从 PsycINFO、PubMed、Web of Science 和 CINAHL 获得的文章进行的。搜索术语和短语，例如“多发性硬化症”、“MS”、“T 细胞”、“发育”、“失调的 T 细胞”和“效应 T 细胞”，用于识别有助于探索研究主题的文章.

结果

MS 的发病机制与 T 细胞的调节、炎症、抑制和效应作用有关。然而，特定 T 细胞亚群在 MS 发育中的实际作用尚不清楚。

讨论

该研究揭示了 MS 和 T 细胞活性之间的重要联系。靶向 T 细胞是开发管理 MS 的新疗法的潜在策略。

结论

MS 是一种复杂的脱髓鞘疾病，影响着全世界数百万人。研究表明，各种类型的 T 细胞，包括效应 T 细胞和调节性 T 细胞，都会影响 MS 的发展和进展。需要进一步的研究来阐明特定 T 细胞群影响 MS 发病机制的潜在机制。