The rapid development of e-commerce has greatly promoted the development of modern logistics. The application level of e-commerce and the application status of modern logistics largely determine the development of a regional economic structure. Under such circumstances, it is particularly important to comprehensively strengthen the research on the impact of e-commerce and modern logistics on the network regional economy. China is as one of the most active regions over the world. Therefore, in this paper, we take the network regional economic as the research object. Firstly, we obtain relevant regional logistics nodes and e-commerce information through wireless networks. Secondly, based on information acquisition, we propose an empirical analysis of the development status of the logistics industry and e-commerce, and we also explain their contributions to regional economic growth. Finally, this paper proposes countermeasures to further increase the contribution of logistics and e-commerce to economic growth. This will provide a reference for building a regionally coordinated logistics-e-commerce system and realizing regional economic integration.