当前位置: X-MOL 学术Asian Pac. J. Allergy Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Toll-like receptor 2-mediated induction of human beta-defensin 2 expression by Leptospira interrogans in human kidney cells.
Asian Pacific Journal of Allergy and Immunology ( IF 5 ) Pub Date : 2020-10-17 , DOI: 10.12932/ap-010420-0798
Naharuthai Inthasin, Chawikan Boonwong, Sutthicha Matamnan, Jintapa Sueasuay, Patimaporn Wongprompitak, Wiwit Tanttibhedhyangkul, Pattama Ekpo

Leptospirosis is a zoonotic disease caused by Leptospira interrogans. Severe leptospirosis is often accompanied by kidney dysfunction caused by chronic infection. The kidney pathology involves bacterial invasion and inflammation caused by pro-inflammatory cytokines. Human beta defensins (hBDs) are antimicrobial peptides induced by microbial infection and/or pro-inflammatory cytokines. One function of hBDs is the recruitment of immune cells that leads to inflammation. However, the expression of hBDs by kidney epithelium in response to pathogenic Leptospira has never been investigated.

中文翻译:

Toll样受体2介导的人钩端螺旋体在人肾细胞中诱导人β-防御素2表达。

钩端螺旋体病是由问号钩端螺旋体引起的人畜共患疾病。严重钩端螺旋体病常伴有慢性感染引起的肾功能不全。肾脏病理涉及促炎性细胞因子引起的细菌入侵和炎症。人β防御素(hBD)是由微生物感染和/或促炎性细胞因子诱导的抗菌肽。hBD的功能之一是募集导致炎症的免疫细胞。然而,从未研究过肾上皮对致病性钩端螺旋体的应答中hBDs的表达。
更新日期:2020-10-21
down
wechat
bug