Itaconate is a mammalian antimicrobial metabolite that inhibits the isocitrate lyases (ICLs) of Mycobacterium tuberculosis. Herein, we report that ICLs form a covalent adduct with itaconate through their catalytic cysteine residue. These results reveal atomic details of itaconate inhibition and provide insights into the catalytic mechanism of ICLs.

中文翻译：

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衣康酸是结核分枝杆菌异柠檬酸裂解酶的共价抑制剂

衣康酸是一种哺乳动物抗菌代谢物，可抑制结核分枝杆菌的异柠檬酸裂解酶 (ICL )。在此，我们报道 ICL 通过其催化半胱氨酸残基与衣康酸形成共价加合物。这些结果揭示了衣康酸抑制的原子细节，并为 ICL 的催化机制提供了见解。