Abstract Cell adhesion is a basic requirement for anchorage-dependent cells to survive on the matrix. It is the first step in a series of cell activities, such as cell diffusion, migration, proliferation, and differentiation. In vivo, cells are surrounded by extracellular matrix (ECM), whose physical and biochemical properties and micromorphology may affect and regulate the function and behavior of cells, causing cell reactions. Cell adhesion is also the basis of communication between cells and the external environment and plays an important role in tissue development. Therefore, the significance of studying cell adhesion in vitro has become increasingly prominent. For instance, in the field of tissue engineering and regenerative medicine, researchers have used artificial surfaces of different materials to simulate the properties of natural ECM, aiming to regulate the behavior of cell adhesion. Understanding the factors that affect cell behavior and how to control cell behavior, including cell adhesion, orientation, migration, and differentiation on artificial surfaces, is essential for materials and life sciences, such as advanced biomedical engineering and tissue engineering. This article reviews various factors affecting cell adhesion as well as the methods and materials often used in investigating cell adhesion.

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用于调节细胞粘附和行为的表面修饰的最新进展

摘要 细胞粘附是贴壁细胞在基质上存活的基本条件。它是细胞扩散、迁移、增殖、分化等一系列细胞活动的第一步。在体内，细胞被细胞外基质（extracellular matrix，ECM）包围，其物理生化特性和微形态可能影响和调节细胞的功能和行为，引起细胞反应。细胞粘附也是细胞与外界环境交流的基础，在组织发育中起着重要作用。因此，体外研究细胞粘附的意义日益突出。例如，在组织工程和再生医学领域，研究人员使用不同材料的人造表面来模拟天然 ECM 的特性，旨在调节细胞粘附的行为。了解影响细胞行为的因素以及如何控制细胞行为，包括人工表面上的细胞粘附、定向、迁移和分化，对于材料和生命科学（例如高级生物医学工程和组织工程）至关重要。本文综述了影响细胞粘附的各种因素以及研究细胞粘附常用的方法和材料。