Biotechnological processes involving the presence of microorganisms are realized by using various types of stirred tanks or laboratory-scale dual-impeller commercial bioreactor. Hydrodynamics and mass transfer rate are crucial parameters describing the functionality and efficiency of bioreactors. Both parameters strictly depend on mixing applied during bioprocesses conducted in bioreactors. Establishing optimum hydrodynamics conditions for the realized process with microorganisms maximizes the yield of desired products. Therefore, our main objective was to analyze and define the main operational hydrodynamic parameters (including flow field, power consumption, mixing time, and mixing energy) and mass transfer process (in this case, gas–liquid transfer) of two different commercial bioreactors (BioFlo^® 115 and BioFlo^® 415). The obtained results are allowed using mathematical relationships to describe the analyzed processes that can be used to predict the mixing process and mass transfer ratio in BioFlo^® bioreactors. The proposed correlations may be applied for the design of a scaled-up or scaled-down bioreactors.

中文翻译：

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BioFlow®生物反应器系统中的流体力学和传质分析

通过使用各种类型的搅拌罐或实验室规模的双叶轮商用生物反应器，可以实现涉及微生物存在的生物技术过程。流体力学和传质速率是描述生物反应器功能和效率的关键参数。这两个参数严格取决于在生物反应器中进行的生物过程中所应用的混合。为利用微生物实现的过程建立最佳流体力学条件，可以使所需产品的产量最大化。因此，我们的主要目标是分析和定义两种不同的商用生物反应器的主要运行流体力学参数（包括流场，功率消耗，混合时间和混合能量）和传质过程（在这种情况下为气液传递）（ BIOFLO ^®115和BIOFLO ^® 415）。将得到的结果使用数学关系来描述可用于预测在BIOFLO混合过程中，传质比的分析方法允许^®生物反应器。所提出的相关性可以用于按比例放大或按比例缩小的生物反应器的设计。