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Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women
Metabolites ( IF 4.1 ) Pub Date : 2020-10-19 , DOI: 10.3390/metabo10100420
Wan-Yu Huang , Dar-Ren Chen , Chew-Teng Kor , Ting-Yu Chen , Po-Te Lin , Joseph Ta Chien Tseng , Hung-Ming Wu

Beyond fertility, follicle-stimulating hormone (FSH) may exert action on adipocytes, which are the major source of adiponectin and leptin, linking to insulin resistance. Therefore, we evaluated the relationships between FSH and adipocyte-derived hormones. This cross-sectional study enrolled postmenopausal women aged 40–65 years. The variables measured in this study included clinical parameters, fasting levels of sex hormones, glucose, insulin, and adipokines. A total of 261 women without breast cancer, 88 women with breast cancer receiving tamoxifen, and 59 women with breast cancer receiving additional gonadotropin-releasing hormone analogs were enrolled in this study. Significant differences in the levels of adiponectin, leptin, and FSH were observed between the non-breast cancer group and the breast cancer groups. Spearman’s rank test revealed significant associations of FSH with either body mass index (BMI) or homeostatic model assessment of insulin resistance (HOMA-IR) values in the non-breast cancer group. After adjusting for BMI, age, and menopause duration, FSH levels were significantly associated with adiponectin (p < 0.001) and the leptin-to-adiponectin ratio (p = 0.008) in the non-breast cancer group, but they were only significantly associated with adiponectin (p = 0.001) in the breast cancer group receiving tamoxifen. Our data show that FSH levels are independently associated with adiponectin levels in postmenopausal women, suggesting that adiponectin may link FSH to metabolic relationships in postmenopausal female.

中文翻译:

绝经后妇女促卵泡激素与脂联素的关系

除生育能力外,促卵泡激素(FSH)还可对脂肪细胞发挥作用,而脂肪细胞是脂联素和瘦素的主要来源,与胰岛素抵抗有关。因此,我们评估了FSH与脂肪细胞源性激素之间的关系。这项横断面研究纳入了40-65岁的绝经后妇女。在这项研究中测量的变量包括临床参数,性激素,葡萄糖,胰岛素和脂肪因子的禁食水平。本研究共纳入261名无乳腺癌的女性,88名接受他莫昔芬的乳腺癌女性和59名接受另外的促性腺激素释放激素类似物的乳腺癌女性。在非乳腺癌组和乳腺癌组之间观察到脂联素,瘦素和FSH水平的显着差异。Spearman等级检验显示非乳腺癌组中FSH与体重指数(BMI)或胰岛素抵抗稳态模型评估(HOMA-IR)值显着相关。在调整了BMI,年龄和更年期持续时间之后,FSH水平与脂联素(在非乳腺癌组中,p <0.001)和瘦素与脂联素之比(p = 0.008),但在接受他莫昔芬的乳腺癌组中,它们仅与脂联素(p = 0.001)显着相关。我们的数据显示,绝经后女性中FSH水平与脂联素水平独立相关,这表明脂联素可能将FSH与绝经后女性的代谢关系联系起来。
更新日期:2020-10-19
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