The chromogranin A1‐373 fragment reveals how a single change in the protein sequence exerts strong cardioregulatory effects by engaging neuropilin‐1,Acta Physiologica

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The chromogranin A1‐373 fragment reveals how a single change in the protein sequence exerts strong cardioregulatory effects by engaging neuropilin‐1
Acta Physiologica ( IF 6.3 ) Pub Date : 2020-10-18 , DOI: 10.1111/apha.13570
Carmine Rocca ₁ , Fedora Grande ₂ , Maria Concetta Granieri ₁ , Barbara Colombo ₃ , Anna De Bartolo _{1,

4} , Francesca Giordano ₄ , Vittoria Rago ₄ , Nicola Amodio ₅ , Bruno Tota _{1,

6} , Maria Carmela Cerra ₆ , Bruno Rizzuti ₇ , Angelo Corti ₃ , Tommaso Angelone _{1,

8} , Teresa Pasqua _{1,

9}

Affiliation

Laboratory of Cellular and Molecular Cardiovascular Patho-Physiology, Department of Biology, E. and E.S., University of Calabria, Rende, Italy.
Laboratory of Medicinal and Analytical Chemistry, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Division of Experimental Oncology, Vita-Salute San Raffaele University-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Laboratory of Organ and System Physiology, Department of Biology, E. and E.S., University of Calabria, Rende, Italy.
CNR-NANOTEC, Licryl-UOS Cosenza and CEMIF.Cal, Department of Physics, University of Calabria, Rende, Italy.
National Institute of Cardiovascular Research (INRC), Bologna, Italy.
"Fondazione Umberto Veronesi", Milan, Italy.

Chromogranin A (CgA), a 439‐residue long protein, is an important cardiovascular regulator and a precursor of various bioactive fragments. Under stressful/pathological conditions, CgA cleavage generates the CgA_1‐373 proangiogenic fragment. The present work investigated the possibility that human CgA_1‐373 influences the mammalian cardiac performance, evaluating the role of its C‐terminal sequence.

中文翻译：

嗜铬粒蛋白 A1-373 片段揭示了蛋白质序列的单一变化如何通过结合神经纤维蛋白-1 发挥强大的心脏调节作用

嗜铬粒蛋白 A (CgA) 是一种 439 个残基的长蛋白，是重要的心血管调节剂和各种生物活性片段的前体。在压力/病理条件下，CgA 裂解产生 CgA _1-373促血管生成片段。目前的工作调查了人类 CgA _1-373影响哺乳动物心脏性能的可能性，评估了其 C 端序列的作用。

更新日期：2020-10-18

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