A simple and efficient one‐pot three‐component azide‐alkyne cycloaddition of 5‐chloro‐1‐phenyl‐pyrazole‐4‐carbaldehyde with 2‐(prop‐2‐yn‐1‐ylthio)‐5‐(substituted phenoxy)methyl‐1,3,4‐oxadiazole and sodium azide is reported. The newly synthesized compounds were characterized by spectral and analytical data. They were screened for in vitro anti‐inflammatory activity by bovine serum albumin denaturation assay. All the tested compounds showed moderate anti‐inflammatory activity, whereas three compounds (4d, 4i, and 4k) showed excellent activity comparable with that of the standard drug diclofenac sodium. The quantitative structure‐activity relationship (QSAR) study was carried out for anti‐inflammatory activities of the synthesized compounds and developed a QSAR model. Inspired by their in vitro anti‐inflammatory activities, they were docked to the active site of COX‐2 to know the anti‐inflammatory potency in silico.

中文翻译：

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一锅三组分叠氮化物-炔烃环加成反应：束缚的新吡唑，1,2,3-三唑和恶二唑的合成及其抗炎，定量结构活性关系和对接研究

5-氯-1-苯基-吡唑-4-甲醛与2-（丙-2-炔-1-基硫基）-5-（取代苯氧基）甲基的简单高效单锅三组分叠氮炔环加成-1,3,4-恶二唑和叠氮化钠的报道。通过光谱和分析数据对新合成的化合物进行了表征。通过牛血清白蛋白变性试验筛选它们的体外抗炎活性。所有测试的化合物均显示出中等的抗炎活性，而三种化合物（4d，4i和4k）显示出与标准药物双氯芬酸钠相当的出色活性。对合成化合物的抗炎活性进行了定量构效关系（QSAR）研究，并建立了QSAR模型。受到其体外抗炎活性的启发，他们被停靠在COX-2的活性位点，以了解其抗炎能力。