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The TOTAL trial dilemma: A survey among professionals on equipoise regarding fetal therapy for severe congenital diaphragmatic hernia
Prenatal Diagnosis ( IF 3 ) Pub Date : 2020-10-19 , DOI: 10.1002/pd.5849
Simen Vergote 1 , Daniel Pizzolato 2 , Francesca Russo 1 , Kris Dierickx 2 , Jan Deprest 1, 3 , Neeltje Crombag 1
Affiliation  

Running randomized clinical trials (RCT) in fetal therapy is challenging. This is no different for fetoscopic endoluminal tracheal occlusion (FETO) for severe left‐sided Congenital Diaphragmatic Hernia (CDH). We assessed the knowledge, attitude and practice (KAP) of maternal‐fetal medicine specialists toward the antenatal management of CDH, and the randomized controlled clinical (RCT) “Tracheal Occlusion To Accelerate Lung growth‐trial.”

中文翻译:

TOTAL 试验困境:关于重度先天性膈疝胎儿治疗平衡的专业人士调查

在胎儿治疗中进行随机临床试验 (RCT) 具有挑战性。对于重度左侧先天性膈疝 (CDH) 的胎儿镜腔内气管闭塞 (FETO) 而言,这没有什么不同。我们评估了母胎医学专家对 CDH 产前管理的知识、态度和实践 (KAP),以及随机对照临床 (RCT) “气管闭塞加速肺生长试验”。
更新日期:2020-10-19
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