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Hippocampal subregional volume changes in elders classified using positron emission tomography‐based Alzheimer's biomarkers of β‐amyloid deposition and neurodegeneration
Journal of Neuroscience Research ( IF 4.2 ) Pub Date : 2020-10-18 , DOI: 10.1002/jnr.24739
Geraldo Busatto Filho 1 , Fabio Luiz de Souza Duran 1 , Paula Squarzoni 1 , Artur Martins Novaes Coutinho 2 , Pedro Gomes Penteado Rosa 1 , Leticia Torralbo 1 , Clarice Gameiro da Fonseca Pachi 1 , Naomi Antunes da Costa 1 , Fabio Henrique de Gobbi Porto 1 , Cleudiana Lima Carvalho 1 , Sonia Maria Dozzi Brucki 3 , Ricardo Nitrini 3 , Orestes Vicente Forlenza 4 , Claudia da Costa Leite 5 , Carlos Alberto Buchpiguel 2 , Daniele de Paula Faria 2
Affiliation  

Changes in hippocampal subfield volumes (HSV) along the Alzheimer's disease (AD) continuum have been scarcely investigated to date in elderly subjects classified based on the presence of β‐amyloid aggregation and signs of neurodegeneration. We classified patients (either sex) with mild dementia compatible with AD (n = 35) or amnestic mild cognitive impairment (n = 39), and cognitively unimpaired subjects (either sex; n = 26) using [11C]PIB‐PET to assess β‐amyloid aggregation (A+) and [18F]FDG‐PET to account for neurodegeneration ((N)+). Magnetic resonance imaging‐based automated methods were used for HSV and white matter hyperintensity (WMH) measurements. Significant HSV reductions were found in A+(N)+ subjects in the presubiculum/subiculum complex and molecular layer, related to worse memory performance. In both the A+(N)+ and A+(N)− categories, subicular volumes were inversely correlated with the degree of Aβ deposition. The A−(N)+ subgroup showed reduced HSV relative to the A−(N)− subgroup also in the subiculum/presubiculum. Combining all (N)− subjects, HSV were lower in subjects presenting significant cognitive decline irrespective of A+/A− classification (controlling for WMH load); these between‐group differences were detected again in the presubiculum, but also involved the CA4 and granular layer. These findings demonstrate that differential HSV reductions are detectable both in (N)+ and (N)− categories along the AD continuum, and are directly related to the severity of cognitive deficits. HSV reductions are larger both in A+(N)+ and A+(N)− subjects in direct proportion to the degree of Aβ deposition. The meaningful HSV reductions detected in the A−(N)+ subgroup highlights the strength of biomarker‐based classifications outside of the classical AD continuum.

中文翻译:

使用基于正电子发射断层扫描的阿尔茨海默病 β-淀粉样蛋白沉积和神经变性生物标志物分类的老年人海马亚区域体积变化

迄今为止,在根据 β-淀粉样蛋白聚集和神经变性迹象进行分类的老年受试者中,几乎没有研究过海马亚区体积 (HSV) 沿阿尔茨海默病 (AD) 连续体的变化。我们 使用 [ 11 C]PIB-PET 对患有与 AD 相容的轻度痴呆 ( n  = 35) 或遗忘性轻度认知障碍 ( n  = 39) 的患者(无论性别)和认知未受损的受试者(无论性别;n = 26)进行分类以评估 β-淀粉样蛋白聚集 (A+) 和 [ 18F]FDG-PET 来解释神经变性 ((N)+)。基于磁共振成像的自动化方法用于 HSV 和白质高信号 (WMH) 测量。在前下骨/下骨复合物和分子层的 A+(N)+ 受试者中发现了显着的 HSV 减少,这与较差的记忆性能有关。在 A+(N)+ 和 A+(N)- 类别中,皮下体积与 Aβ 沉积程度呈负相关。A-(N)+ 亚组显示出相对于 A-(N)- 亚组的 HSV 减少,同样在下托/下托中。结合所有 (N)- 受试者,无论 A+/A- 分类如何(控制 WMH 负荷),表现出显着认知能力下降的受试者的 HSV 均较低;这些组间差异在 presubculum 中再次检测到,但也涉及 CA4 和颗粒层。这些发现表明,在沿着 AD 连续体的 (N)+ 和 (N)- 类别中均可检测到不同的 HSV 减少,并且与认知缺陷的严重程度直接相关。A+(N)+ 和 A+(N)- 受试者的 HSV 减少量更大,与 Aβ 沉积的程度成正比。在 A-(N)+ 亚组中检测到的有意义的 HSV 减少突出了经典 AD 连续体之外基于生物标志物的分类的强度。
更新日期:2020-12-20
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