There is a growing demand for polymer fiber scaffolds for biomedical applications and tissue engineering. Biodegradable polymers such as polycaprolactone have attracted particular attention due to their applicability to tissue engineering and optical neural interfacing. Here we report on a scalable and inexpensive fiber fabrication technique, which enables the drawing of PCL fibers in a single process without the use of auxiliary cladding. We demonstrate the possibility of drawing PCL fibers of different geometries and cross‐sections, including solid‐core, hollow‐core, and grooved fibers. The solid‐core fibers of different geometries are shown to support cell growth, through successful MCF‐7 breast cancer cell attachment and proliferation. We also show that the hollow‐core fibers exhibit a relatively stable optical propagation loss after submersion into a biological fluid for up to 21 days with potential to be used as waveguides in optical neural interfacing. The capacity to tailor the surface morphology of biodegradable PCL fibers and their non‐cytotoxicity make the proposed approach an attractive platform for biomedical applications and tissue engineering.

中文翻译：

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用于生物医学应用的具有定制形貌的热拉伸可生物降解纤维

用于生物医学应用和组织工程的聚合物纤维支架的需求不断增长。聚己内酯等可生物降解聚合物因其在组织工程和光学神经接口方面的适用性而受到特别关注。在这里，我们报告了一种可扩展且廉价的光纤制造技术，该技术可以在单个过程中拉制 PCL 光纤，而无需使用辅助包层。我们展示了拉制不同几何形状和横截面的 PCL 纤维的可能性，包括实心、空心和凹槽纤维。通过成功的 MCF-7 乳腺癌细胞附着和增殖，不同几何形状的实心纤维显示支持细胞生长。我们还表明，空芯光纤在浸入生物流体长达 21 天后表现出相对稳定的光传播损耗，有可能用作光神经接口中的波导。定制可生物降解 PCL 纤维表面形态的能力及其非细胞毒性使所提出的方法成为生物医学应用和组织工程的有吸引力的平台。