Freezing of gait (FoG) is one of the main reasons for movement initiation disorders and abnormal coupling of posture and gait in Parkinson's disease (PD). Patients with FoG have poor postural control when compared to patients without FoG. However, the nature of the interrelationship between FoG and domains of postural control remains unknown. The aim of this study was to estimate the association between different domains of postural control and severity of FoG in patients with moderate‐to‐severe PD. Thirty patients with idiopathic PD with FoG (age range 45–80 years, Hoehn & Yahr stages 3 and 4) participated in the study. We evaluated objective (FoG‐ratio during turning task) and subjective (New Freezing of Gait Questionnaire, NFoG‐Q) measures of FoG severity, reactive postural adjustments in response to an external perturbation, first step anticipatory adjustment for step initiation and quiet standing stability. In the multiple regression analysis, step initiation was the strongest significant correlation of the NFoG‐Q score explaining 23% of the variance of the assessment. For the objective FoG measure, mediolateral CoP amplitude in quiet standing and mediolateral CoP amplitude in step initiation explained 39% of the variance of the FoG‐ratio. As main conclusions, this study identified the association between objective and subjective measure for FoG severity and postural control domains. The results support conducting step initiation training during rehabilitation of individuals with FoG.

中文翻译：

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中度至重度帕金森氏病患者的步态冻结与姿势控制是否相关？

步态冻结（FoG）是导致帕金森氏病（PD）的运动引发障碍以及姿势和步态异常耦合的主要原因之一。与没有FoG的患者相比，有FoG的患者的姿势控制较差。但是，FoG和姿势控制域之间的相互关系的性质仍然未知。这项研究的目的是评估中度至重度PD患者的姿势控制的不同领域与FoG严重程度之间的关联。30例特发性PD伴FoG的患者（年龄范围45-80岁，Hoehn和Yahr第3和4期）参加了研究。我们评估了FoG严重程度的客观指标（转弯任务时的Fog比率）和主观指标（步态冻结新问卷，NFoG-Q），针对外部扰动的反应性姿势调整，第一步预期调整，用于步伐启动和安静的站立稳定性。在多元回归分析中，步长启动是NFoG-Q评分的最强显着相关性，解释了评估差异的23％。对于客观FoG量度，安静站立时的中外侧CoP幅度和阶跃启动中的中外侧CoP幅度解释了FoG-ratio的39％的变化。作为主要结论，本研究确定了FoG严重程度和姿势控制域的客观和主观度量之间的关联。结果支持在FoG患者康复期间进行逐步启动训练。逐步启动是NFoG-Q评分的最强显着相关性，解释了评估差异的23％。对于客观FoG量度，安静站立时的中外侧CoP幅度和阶跃启动中的中外侧CoP幅度解释了FoG-ratio的39％的变化。作为主要结论，本研究确定了FoG严重程度与姿势控制域的客观和主观度量之间的关联。结果支持在FoG患者康复期间进行逐步启动训练。逐步启动是NFoG-Q评分的最强显着相关性，解释了评估差异的23％。对于客观FoG量度，安静站立时的中外侧CoP幅度和阶跃启动中的中外侧CoP幅度解释了FoG-ratio的39％的变化。作为主要结论，本研究确定了FoG严重程度和姿势控制域的客观和主观度量之间的关联。结果支持在FoG患者康复期间进行逐步启动训练。这项研究确定了FoG严重程度与姿势控制域的客观和主观度量之间的关联。结果支持在FoG患者康复期间进行逐步启动训练。这项研究确定了FoG严重程度与姿势控制域的客观和主观度量之间的关联。结果支持在FoG患者康复期间进行逐步启动训练。