Pharmacoresistance and the lack of disease‐modifying actions of current antiseizure drugs persist as major challenges in the treatment of epilepsy. Experimental models of chemoconvulsant‐induced status epilepticus remain the models of choice to discover potential antiepileptogenic drugs, but doubts remain as to the extent to which they model human pathophysiology. The aim of the present study was to compare the molecular landscape of the intra‐amygdala kainic acid model of status epilepticus in mice with findings in resected brain tissue from patients with drug‐resistant temporal lobe epilepsy (TLE).

中文翻译：

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小鼠杏仁核内红藻氨酸模型海马转录组与人颞叶癫痫的高度一致性

目前抗癫痫药物的耐药性和缺乏缓解疾病的作用仍然是癫痫治疗的主要挑战。化学惊厥药诱导的癫痫持续状态的实验模型仍然是发现潜在抗癫痫药物的首选模型，但对它们模拟人类病理生理学的程度仍存疑虑。本研究的目的是比较小鼠杏仁核内红藻氨酸模型的分子图谱与耐药性颞叶癫痫 (TLE) 患者切除脑组织的发现。