带药物释放的3D打印自粘绷带，用于周围神经修复,Advanced Science

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带药物释放的3D打印自粘绷带，用于周围神经修复
Advanced Science ( IF 15.1 ) Pub Date : 2020-10-19 , DOI: 10.1002/advs.202002601
Jiumeng Zhang ₁ , Yuwen Chen ₁ , Yulan Huang ₁ , Wenbi Wu ₁ , Xianming Deng ₂ , Haofan Liu ₁ , Rong Li ₁ , Jie Tao ₁ , Xiang Li ₃ , Xuesong Liu ₄ , Maling Gou ₁

Affiliation

周围神经损伤是一种常见疾病，通常会导致残疾并向医生提出挑战。药物可释放的生物材料为调节神经修复相关的微环境进行神经修复提供了可靠的工具。在这里，设计了一种自粘绷带，可以在受伤的神经周围形成包裹物，以促进神经再生和恢复。通过3D打印技术，可以制备具有特殊结构的绷带，该绷带由两个不同的水凝胶层组成，这些水凝胶层可以通过点击反应相互粘附。纳米药物被封装成具有光栅结构的一层。包裹受伤的神经，绷带的光栅层靠近受伤部位。该药物可主要通过改善雪旺细胞的增殖和迁移而释放到包裹的内部，以促进神经修复。在这项研究中，绷带用于辅助神经泻术治疗完全坐骨神经横断，而大鼠没有明显的缺陷。结果表明，自粘能力可以简化安装过程，而载药绷带可以促进受损神经的修复。演示的3D打印自粘绷带在辅助神经性腹泻神经修复中具有潜在的应用价值。

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A 3D‐Printed Self‐Adhesive Bandage with Drug Release for Peripheral Nerve Repair

Peripheral nerve injury is a common disease that often causes disability and challenges surgeons. Drug‐releasable biomaterials provide a reliable tool to regulate the nerve healing‐associated microenvironment for nerve repair. Here, a self‐adhesive bandage is designed that can form a wrap surrounding the injured nerve to promote nerve regeneration and recovery. Via a 3D printing technique, the bandage is prepared with a special structure and made up of two different hydrogel layers that can adhere to each other by a click reaction. The nanodrug is encapsulated in one layer with a grating structure. Wrapping the injured nerve, the grating layer of the bandage is closed to the injured site. The drug can be mainly released to the inner area of the wrap to promote the nerve repair by improving the proliferation and migration of Schwann cells. In this study, the bandage is used to assist the neurorrhaphy for the treatment of complete sciatic nerve transection without obvious defect in rats. Results indicate that the self‐adhesive capacity can simplify the installation process and the drug‐loaded bandage can promote the repairing of injured nerves. The demonstrated 3D‐printed self‐adhesive bandage has potential application in assisting the neurorrhaphy for nerve repair.

更新日期：2020-12-03

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