The objectives for this study were to evaluate differences in serum concentration of metabolites, macro minerals and hepatic enzymes at pre and postpartum time-points in dairy cows diagnosed with clinical metritis, hypocalcaemia or ketosis postpartum. A total of 144 Holstein cows from 11 commercial dairy herds in Alberta, (Western Canada) were enrolled in this study. Cows with clinical metritis had lower serum concentrations of glutamate dehydrogenase (GLDH) at pre and postpartum and lower total Ca, albumin, urea, and cholesterol at postpartum when compared to control cows. Cows with hypocalcaemia had greater serum concentrations of Na, Cl, and calculated osmolarity (CalOsmo) at prepartum and lower concentration of total serum Ca, glucose, cholesterol, gamma-glutamyl transpeptidase (GGT), GLDH, total protein and albumin at postpartum. Prepartum concentrations of serum non-esterified fatty acids (NEFA), beta hydroxybutyrate (BHB), Cl, albumin/globulin ratio (A/G), Na, K and sum of Na and K were greater in ketotic cows when compared with control cows. Cows with ketosis had greater serum postpartum concentrations of NEFA, BHB, GGT and aspartate transaminase (AST) when compared with control cows. Prepartum serum Na and Cl concentrations and CalOsmo were greater in cows diagnosed with hypocalcaemia or ketosis when compared with control cows. Furthermore, postpartum Ca, cholesterol, albumin and GLDH were significantly affected by hypocalcaemia or clinical metritis and GGT by hypocalcaemia or ketosis. Finally, postpartum serum haptoglobin increased in all disease groups when compared with control cows. These results suggest common metabolic features for clinical metritis, hypocalcaemia and ketosis in dairy cows in addition to the specific ones.

这项研究的目的是评估被诊断患有临床子宫炎，低血钙或产后酮症的奶牛在产前和产后时间点血清代谢物，大量矿物质和肝酶的血清浓度差异。来自加拿大西部艾伯塔省11个商业奶牛场的144头荷斯坦奶牛参加了这项研究。与对照组相比，患有临床子宫炎的母牛产前和产后血清谷氨酸脱氢酶（GLDH）浓度较低，而产后总Ca，白蛋白，尿素和胆固醇含量较低。低钙血症的母牛产前血中的Na，Cl含量较高，计算出的渗透压（CalOsmo），而产后总血清Ca，葡萄糖，胆固醇，γ-谷氨酰转肽酶（GGT），GLDH，总蛋白和白蛋白的浓度较低。与对照奶牛相比，生酮奶牛的血清非酯化脂肪酸（NEFA），β羟基丁酸酯（BHB），Cl，白蛋白/球蛋白比（A / G），Na，K以及Na和K的总和的产前浓度更高。与对照组相比，患有酮症的母牛的产后血清NEFA，BHB，GGT和天冬氨酸转氨酶（AST）浓度更高。与对照奶牛相比，诊断为低钙血症或酮病的奶牛的产前血清Na和Cl浓度以及CalOsmo更高。此外，产后钙，胆固醇，白蛋白和GLDH明显受低血钙症或临床子宫炎的影响，而GGT受低血钙症或酮症的影响。最后，与对照牛相比，所有疾病组的产后血清触珠蛋白均升高。这些结果表明临床子宫炎常见的代谢特征，