Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used over-the-counter drugs and their uncontrolled disposal is a significant environmental concern. Although their fluorescent sensing is a desirable method of detection for its sensitivity and simplicity, the structural similarity of the drugs makes the design of selective sensors highly challenging. A thiourea-based fluorescent functional monomer was identified in this work to enable highly efficient synthesis of molecularly imprinted nanoparticle (MINP) sensors for NSAIDs such as Indomethacin or Tolmetin. Micromolar binding affinities were obtained in aqueous solution, with binding selectivities comparable to those reported for polyclonal antibodies. The detection limit was ~50 ng/mL in aqueous solution, and common carboxylic acids such as acetic acid, benzoic acid, and citric acid showed negligible interference.

非甾体抗炎药 (NSAID) 是广泛使用的非处方药，其不受控制的处置是一个重大的环境问题。尽管它们的荧光传感因其灵敏度和简单性而成为一种理想的检测方法，但药物的结构相似性使得选择性传感器的设计极具挑战性。在这项工作中发现了一种基于硫脲的荧光功能单体，可以高效合成用于非甾体抗炎药（如吲哚美辛或托美汀）的分子印迹纳米颗粒 (MINP) 传感器。微摩尔结合亲和力是在水溶液中获得的，结合选择性与多克隆抗体报道的结合选择性相当。水溶液中的检测限为~50 ng/mL，常见的羧酸如乙酸、苯甲酸、