While substantial evidence points towards obesity and associated cardiometabolic disorders being a major factor for poor outcomes in SARS-CoV2 infections (COVID-19), the complexity of the interplay between these two pandemics is becoming apparent. Indeed, as previously defined, this interaction between obesity and COVID-19 represents a ‘syndemic’ that requires both current and ongoing attention. At a mechanistic level the chronic inflammatory environment of obesity predisposes to life threatening events such as cytokine storm and enhanced coagulopathy. Obesity and its management are affected by diverse factors manifested at societal, educational, racial, and nutritional levels. A multidisciplinary approach is required to manage obese and type 2 diabetic patients, not only during the current COVID-19 crisis, but to decrease the growing burden of cardiometabolic disease and associated cardiovascular complications impacting future viral pandemics. Further, this syndemic has highlighted disparities in healthcare which need to be addressed to achieve equality in health outcomes in patients infected with COVID-19.

虽然大量证据表明肥胖和相关的心脏代谢紊乱是SARS-CoV2感染（COVID-19）不良结局的主要因素，但这两种大流行之间相互作用的复杂性正在变得明显。确实，如先前所定义，肥胖与COVID-19之间的这种相互作用代表了一种“综合症”，需要当前和持续的关注。从机理上讲，肥胖的慢性炎性环境易引发威胁生命的事件，例如细胞因子风暴和凝血功能增强。肥胖及其管理受到社会，教育，种族和营养水平上各种因素的影响。不仅在当前的COVID-19危机期间，还需要采用多学科方法来管理肥胖和2型糖尿病患者，但要减轻心脏代谢疾病和相关的心血管并发症的负担，从而影响未来的病毒性大流行。此外，这种综合症突显了医疗保健方面的差异，需要解决这些差异以实现感染COVID-19的患者在健康结果方面的平等。