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Regioselective synthesis and antioxidant activity of a novel class of mono and C2-symmetric bis-1,2,3-triazole and acridinedione grafted macromolecules
Journal of Saudi Chemical Society ( IF 5.6 ) Pub Date : 2020-10-19 , DOI: 10.1016/j.jscs.2020.10.001
Rajesh Raju , Shanmugam Rajasekar , Raghavachary Raghunathan , Natarajan Arumugam , Abdulrahman I. Almansour , Raju Suresh Kumar

An expedient regioselectivesynthesis of novel mono, C2-symmetric bis-triazole and acridinedione bridged macromolecules has been achieved in good yields employing intermolecular Cu(I) catalyzed azide and alkyne click reaction. Synthesis of O-propargyl acridinedione was achieved in three good yielding steps starting from dimedone, while the symmetrical aliphatic and aryl bis-azides were derived from appropriate dibromides in the presence of sodium azide in dry DMF. The synthesized mono and C2-symmetric bis-macromolecules have been elucidated by 1H, 13C, elemental and mass spectroscopic analysis. The antioxidant activity of synthesized compounds has also been investigated.

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中文翻译:

一类新的单和C 2对称双1,2,3-三唑和a啶二酮接枝的大分子的区域选择性合成和抗氧化活性

利用分子间Cu(I)催化的叠氮化物和炔烃点击反应,以高收率实现了新型单,C 2对称双三唑和a啶二酮桥联的大分子的区域选择性合成。从二甲酮开始,在三个良好的产率步骤中完成了O-炔丙基yl啶二酮的合成,而对称的脂族和芳基双叠氮化物是在干燥的DMF中,在叠氮化钠存在下,由适当的二溴化物衍生而来的。通过1 H,13 C,元素和质谱分析已阐明了合成的单和C 2对称双大分子。还研究了合成化合物的抗氧化活性。

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更新日期:2020-10-30
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