Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk,Journal of Allergy and Clinical Immunology

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Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk
Journal of Allergy and Clinical Immunology ( IF 14.2 ) Pub Date : 2020-10-19 , DOI: 10.1016/j.jaci.2020.10.009
Howard H F Tang ₁ , Anna Lang ₂ , Shu Mei Teo ₃ , Louise M Judd ₄ , Ronald Gangnon ₅ , Michael D Evans ₅ , Kristine E Lee ₅ , Rose Vrtis ₂ , Patrick G Holt ₆ , Robert F Lemanske ₂ , Daniel J Jackson ₂ , Kathryn E Holt ₇ , Michael Inouye ₈ , James E Gern ₂

Affiliation

Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; School of BioSciences, University of Melbourne, Melbourne, Australia.
Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis.
Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Australia.
Department of Biomedical Informatics, University of Wisconsin-Madison, Madison, Wis.
Children's Telethon Institute and the University of Western Australia, Perth, Australia.
Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Australia; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; The Alan Turing Institute, London, United Kingdom.

Background

Studies indicate that the nasal microbiome may correlate strongly with the presence or future risk of childhood asthma.

Objectives

In this study, we tested whether developmental trajectories of the nasopharyngeal microbiome in early life and the composition of the microbiome during illnesses were related to risk of childhood asthma.

Methods

Children participating in the Childhood Origins of Asthma study (N = 285) provided nasopharyngeal mucus samples in the first 2 years of life, during routine healthy study visits (at 2, 4, 6, 9, 12, 18, and 24 months of age), and during episodes of respiratory illnesses, all of which were analyzed for respiratory viruses and bacteria. We identified developmental trajectories of early-life microbiome composition, as well as predominant bacteria during respiratory illnesses, and we correlated these with presence of asthma at 6, 8, 11, 13, and 18 years of age.

Results

Of the 4 microbiome trajectories identified, a Staphylococcus-dominant microbiome in the first 6 months of life was associated with increased risk of recurrent wheezing by age 3 years and asthma that persisted throughout childhood. In addition, this trajectory was associated with the early onset of allergic sensitization. During wheezing illnesses, detection of rhinoviruses and predominance of Moraxella were associated with asthma that persisted throughout later childhood.

Conclusion

In infancy, the developmental composition of the microbiome during healthy periods and the predominant microbes during acute wheezing illnesses are both associated with the subsequent risk of developing persistent childhood asthma.

中文翻译：

婴儿期鼻咽微生物群的发育模式与哮喘风险相关

背景

研究表明，鼻腔微生物群可能与儿童哮喘的存在或未来风险密切相关。

目标

在这项研究中，我们测试了早期鼻咽微生物群的发育轨迹和疾病期间微生物群的组成是否与儿童哮喘风险有关。

方法

参与儿童哮喘起源研究的儿童 (N = 285) 在生命的前 2 年，在常规健康研究访问期间（在 2、4、6、9、12、18 和 24 个月大时）提供了鼻咽粘液样本)，并且在呼吸系统疾病发作期间，所有这些都被分析了呼吸道病毒和细菌。我们确定了生命早期微生物组组成的发育轨迹，以及呼吸系统疾病期间的主要细菌，并将这些与 6、8、11、13 和 18 岁时的哮喘相关联。