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Hepatotoxic and neuroendocrine effects in physicians occupationally exposed to most modern halogenated anesthetics and nitrous oxide
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-10-18 , DOI: 10.1016/j.etap.2020.103515
Aline G. Aun , Kátina M. Souza , Júlia L. Guedes , Drielle B.S. Figueiredo , Juliana R. Lara , Mariane A.P. Silva , Leandro G. Braz , Mariana G. Braz

The lack of data on hepatic and hormonal markers for occupational exposure to most modern halogenated anesthetics has stimulated our research, which assessed liver enzymes, high-sensitivity C-reactive protein (hs-CRP) and neuroendocrine response. The study investigated 106 physicians who were categorized in an exposed group (primarily exposed to isoflurane and sevoflurane and less to desflurane and nitrous oxide) as well as as a control group. Anesthetic air monitoring was performed, and biological samples were analyzed for the most important liver enzymes, hs-CRP, adrenocorticotrophic hormone, cortisol and prolactin. No biomarkers were significantly different between the groups. Exposed males showed significant increases in cortisol and prolactin compared to unexposed males. However, values were within the reference ranges, and 22 % of exposed males versus 5 % of unexposed males exhibited higher prolactin values above the reference range. This study suggests that occupational exposure to the most commonly used inhalational anesthetics is not associated with hepatotoxicity or neurohormonal changes.



中文翻译:

职业暴露于大多数现代卤代麻醉剂和一氧化二氮的医生的肝毒性和神经内分泌作用

缺乏关于大多数现代卤代麻醉剂职业接触的肝和激素标志物的数据,这刺激了我们的研究,该研究评估了肝酶,高敏感性C反应蛋白(hs-CRP)和神经内分泌反应。这项研究调查了106位医师,这些医师被分为暴露组(主要暴露于异氟烷和七氟醚,较少暴露于地氟烷和一氧化二氮)以及对照组。进行了麻醉空气监测,并分析了生物样品中最重要的肝酶,hs-CRP,肾上腺皮质营养激素,皮质醇和催乳激素。两组之间没有明显的生物标志物差异。与未暴露的男性相比,暴露的男性显示皮质醇和催乳激素显着增加。但是,值在参考范围内,相对于5%未曝光的男性,其催乳素值高于参考范围。这项研究表明,职业性接触最常用的吸入麻醉药与肝毒性或神经激素变化无关。

更新日期:2020-10-30
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