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Dinitrosyl Iron Complexes with Thiol-Containing Ligands Can Suppress Viral Infections as Donors of the Nitrosonium Cation (Hypothesis)
Biophysics Pub Date : 2020-07-01 , DOI: 10.1134/s0006350920040260
A F Vanin 1, 2
Affiliation  

The appropriateness of verification of the possible antiviral effect of dinitrosyl iron complexes with thiol-containing ligands as donors of nitrosonium cations (NO + ) is argued. There is reason to hope that treatment of the human respiratory tract and lungs with sprayed solutions of dinitrosyl iron complexes with glutathione or N-acetylcysteine (NAC) ​​as NO + donors during COVID-19 infection can initiate S-nitrosylation of cellular proteases and thereby suppress viral infection.

中文翻译:

二亚硝基铁与含硫醇配体的络合物可以作为亚硝基阳离子供体抑制病毒感染(假设)

争论了验证二亚硝基铁配合物与含硫醇配体作为亚硝鎓阳离子(NO + )供体可能的抗病毒作用的适当性。有理由希望,在 COVID-19 感染期间,用二亚硝基铁复合物与谷胱甘肽或 N-乙酰半胱氨酸 (NAC) 作为 NO + 供体的喷雾溶液治疗人类呼吸道和肺部,可以启动细胞蛋白酶的 S-亚硝基化和从而抑制病毒感染。
更新日期:2020-07-01
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