This review is focused on literature data and our own research of the nontrivial quinoid pathway for the oxidation of adrenaline. All catecholamines can be oxidized similarly with formation of corresponding aminochromes. This process is simulated in vitro in an alkaline medium and is known as the adrenaline autoxidation chain reaction, whose products are adrenochrome and radical compounds, superoxide anions (\({\text{O}}_{2}^{{ - {\kern 1pt} \centerdot }}\)), and other. This reaction was previously used to determine the activity of superoxide dismutase as a model of superoxide generation. We have proposed various new methodical approaches that allow the determination of the enzyme activity and reveal the anti/prooxidant properties of various compounds and materials. This pathway of conversion of one of the catecholamines (dopamine) is currently described as a “preclinical model of Parkinson’s disease.” In this regard, we have proposed the reaction of adrenaline autoxidation to be used in search for substances that can inhibit the process of quinoid oxidation, that is, to identify potential neuroprotective agents. Experimental and theoretical studies of this reaction expand the understanding of the mechanisms of free radical processes that occur in the body.

这篇综述的重点是文献数据和我们自己对肾上腺素氧化非平凡醌途径的研究。所有儿茶酚胺均可类似地被氧化，形成相应的氨基染料。此过程是在碱性介质中体外模拟的，被称为肾上腺素自氧化链反应，其产物为肾上腺色素和自由基化合物，超氧阴离子（\（{\ text {O}} _ {2} ^ {{-{\核心1pt} \ centerdot}} \））， 和别的。该反应以前被用来确定超氧化物歧化酶的活性，作为超氧化物生成的模型。我们已经提出了各种新的方法论方法，这些方法可以测定酶的活性并揭示各种化合物和材料的抗/促氧化性能。儿茶酚胺（多巴胺）之一的这种转化途径目前被描述为“帕金森氏病的临床前模型”。在这方面，我们已经提出肾上腺素自氧化反应用于寻找可以抑制醌型氧化过程的物质，即鉴定潜在的神经保护剂。关于该反应的实验和理论研究扩展了对体内发生的自由基过程机理的理解。