We investigated the effects of the H₂S and CO gasomediators on Ca²⁺-dependent potassium channels and an anion exchanger, which participate in the induction of the hyperpolarization response of the erythrocyte membrane and play an important role in regulation of the volume and deformability of erythrocytes. We showed that in the presence of H₂S and CO donors, the amplitude of the redox-stimulated membrane hyperpolarization decreased significantly due to a decrease in the activity of Ca²⁺-dependent potassium channels. It was found that H₂S and CO eliminate the compression of erythrocytes observed during activation of Ca²⁺-dependent potassium channels or inhibition of the anion exchanger. It was shown that the H₂S donor significantly increases the erythrocyte deformability.

我们研究了H ₂ S和CO气体加香剂对Ca ²⁺依赖性钾通道和阴离子交换剂的影响，它们参与诱导红细胞膜的超极化反应，并在调节体积和可变形性中起重要作用红细胞。我们表明，在H ₂ S和CO供体的存在下，由于Ca ²⁺依赖性钾离子通道活性的降低，氧化还原刺激的膜超极化的幅度显着降低。发现H ₂ S和CO消除了Ca ²⁺活化过程中观察到的红细胞压缩-依赖性钾通道或抑制阴离子交换剂。结果表明，H ₂ S供体显着增加了红细胞的可变形性。