Abstract

A convenient method has been developed for the synthesis of 3,5-bis(hydroxymethyl)adamantan-1-ols via successive nitroxylation of 1,3-bis(acetoxymethyl)adamantanes with fuming nitric acid, alkaline hydrolysis of intermediate 3,5-bis(acetoxymethyl)adamantane-1-yl nitrates, and reaction of the resulting 3,5-bis(hydroxymethyl)adamantan-1-yl nitrates with hydrazine hydrate. 3,5-Bis(hydroxymethyl)adamantan-1-ols have been converted to the corresponding trinitrates by treatment with fuming nitric acids in acetic anhydride.

中文翻译：

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3,5-双（羟甲基）金刚烷-1-醇和3,5-双（硝基氧甲基）金刚烷-1-基硝酸酯的合成

摘要

已开发出一种方便的方法，用于通过将1,3-双（乙酰氧基甲基）金刚烷与发烟硝酸连续硝化，碱性水解中间体3,5-bis来合成3,5-双（羟甲基）金刚烷-1-醇（乙酰氧基甲基）金刚烷-1-基硝酸盐，以及所得的3,5-双（羟甲基）金刚烷-1-基硝酸盐与水合肼的反应。通过在乙酸酐中使用发烟硝酸处理3,5-双（羟甲基）金刚烷-1-醇，已将其转化为相应的三硝酸盐。