Hollow mesoporous silica nanoparticles (HMSNs) have become an attractive drug carrier because of their unique characteristics including stable physicochemical properties, large specific surface area and facile functionalization, especially made into intelligent drug delivery systems (DDSs) for cancer therapy. HMSNs are employed to transport traditional anti-tumor drugs, which can solve the problems of drugs with instability, poor solubility and lack of recognition, etc., while significantly improving the anti-tumor effect. And an unexpected good result will be obtained by combining functional molecules and metal species with HMSNs for cancer diagnosis and treatment. Actually, HMSNs-based DDSs have developed relatively mature in recent years. This review briefly describes how to successfully prepare an ordinary HMSNs-based DDS, as well as its degradation, different stimuli-responses, targets and combination therapy. These versatile intelligent nanoparticles show great potential in clinical aspects.

中空二氧化硅纳米粒子（HMSNs）已成为有吸引力的药物载体，因为它们具有独特的特性，包括稳定的理化性质，大的比表面积和容易的功能化，特别是制成用于癌症治疗的智能药物递送系统（DDS）。HMSN被用于运输传统的抗肿瘤药物，可以解决药物不稳定，溶解度差，缺乏识别等问题，同时大大提高了抗肿瘤效果。通过将功能分子和金属物种与HMSN结合使用，可以在癌症诊断和治疗中获得意想不到的良好结果。实际上，基于HMSN的DDS近年来已经发展得相对成熟。这篇评论简要描述了如何成功地准备一个基于HMSN的普通DDS，以及其降解，不同的刺激反应，目标和联合疗法。这些多功能的智能纳米颗粒在临床方面显示出巨大的潜力。