There is clinical and experimental evidence that in biomedicine, the limit between what we consider normal and what we consider pathological is not always so clear and absolute. Conditions may arise in which, apparently without any explanation, one passes from one condition to another. A key role is played by changes that occur in the microenvironment surrounding a cell population. The terms normal and pathological have no absolute meaning on their own. They have their own meaning only if they are considered in the light of the relationships between the living being and its surrounding environment. Man is able to create new environments instead of passively enduring its changes. Any individual who deviates from a statistically defined normal individual will be considered pathological.

中文翻译：

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正常和病理状态之间的界限

有临床和实验证据表明，在生物医学中，我们认为正常和病理之间的界限并不总是那么明确和绝对。可能会出现条件，显然没有任何解释，一个人从一个条件过渡到另一个条件。细胞群周围微环境中发生的变化起着关键作用。术语正常和病理本身没有绝对的意义。只有根据生物与其周围环境之间的关系来考虑它们，它们才具有自己的意义。人类能够创造新的环境，而不是被动地忍受它的变化。任何偏离统计定义的正常个体的个体都将被认为是病理性的。