Thymus atlanticus is an endemic plant of the Mediterranean region, which has been used in the Moroccan mountain area to treat several diseases. This study aimed to investigate the effect of polyphenol, flavonoid, and saponin fractions derived from this plant on acute and chronic hyperlipidemia in male albino mice. The results indicated that the injection of Triton WR-1339 (20 mg/100 g body weight (B.wt.)) and 6-week administration of a high-fat diet (which is an 81.8% standard diet supplemented with 2% cholesterol, 16% lard, and 0.2% cholic acid) significantly increased plasma total cholesterol, triglycerides and low-density lipoprotein cholesterol (LDL-C), but did not affect high-density lipoprotein cholesterol (HDL-C) levels in mice. Administration of a single dose (2 mg/kg B.wt.) of polyphenol, flavonoid, or saponin fractions significantly suppressed the effect of Triton injection on plasma total cholesterol, triglycerides, and LDL-C. In addition, the supplementation of the high-fat diet with polyphenol fraction (2 mg/kg B.wt./day) prevented the increase of total cholesterol, triglycerides, and LDL-C, and effectively increased HDL-C level when compared to mice feeding only the high-fat diet. In conclusion, phenolic compounds from Thymus atlanticus possess a significant hypocholesterolemic and hypotriglyceridemic effects and, therefore, could have an important role in the management of dyslipidemia.

中文翻译：

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百里香中多酚，类黄酮和皂苷成分对小鼠急慢性高脂血症的影响

胸腺是地中海地区的特有植物，已在摩洛哥山区用于治疗多种疾病。这项研究旨在调查这种植物衍生的多酚，类黄酮和皂苷组分对雄性白化病小鼠急性和慢性高脂血症的影响。结果表明注射Triton WR-1339（20 mg / 100 g体重（B.wt.））并进行6周高脂饮食（81.8％标准饮食，补充2％胆固醇） ，16％的猪油和0.2％的胆酸）可显着增加血浆总胆固醇，甘油三酸酯和低密度脂蛋白胆固醇（LDL-C），但不会影响小鼠的高密度脂蛋白胆固醇（HDL-C）水平。单剂量（2 mg / kg体重）的多酚，类黄酮，或皂苷成分可显着抑制Triton注射液对血浆总胆固醇，甘油三酸酯和LDL-C的影响。此外，在高脂饮食中补充多酚部分（2 mg / kg体重/天）可防止总胆固醇，甘油三酸酯和LDL-C的增加，并且与老鼠只喂高脂饮食。总之，来自胸腺的酚类化合物具有显着的降胆固醇和降甘油三酯作用，因此，在血脂异常的管理中可能具有重要作用。与仅饲喂高脂饮食的小鼠相比，LDL-C和HDL-C水平有效提高。总之，来自胸腺的酚类化合物具有显着的降胆固醇和降甘油三酯作用，因此，在血脂异常的管理中可能具有重要作用。与仅饲喂高脂饮食的小鼠相比，LDL-C和HDL-C水平有效提高。总之，来自胸腺的酚类化合物具有显着的降胆固醇和降甘油三酯作用，因此，在血脂异常的管理中可能具有重要作用。