当前位置: X-MOL 学术Part. Fibre Toxicol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine
Particle and Fibre Toxicology ( IF 10 ) Pub Date : 2020-10-16 , DOI: 10.1186/s12989-020-00372-0
Xiaoli Feng 1 , Yaqing Zhang 2 , Chao Zhang 3 , Xuan Lai 2 , Yanli Zhang 1 , Junrong Wu 2 , Chen Hu 2 , Longquan Shao 2
Affiliation  

Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of NM-mediated autophagy in biomedicine are nonnegligible and require our particular concerns. We collected research on the toxic effects related to NM-mediated autophagy both in vivo and in vitro. Generally, NMs can be delivered into animal models through different administration routes, or internalized by cells through different uptake pathways, exerting varying degrees of damage in tissues, organs, cells, and organelles, eventually being deposited in or excreted from the body. In addition, other biological effects of NMs, such as oxidative stress, inflammation, necroptosis, pyroptosis, and ferroptosis, have been associated with autophagy and cooperate to regulate body activities. We therefore highlight that NM-mediated autophagy serves as a double-edged sword, which could be utilized in the treatment of certain diseases related to autophagy dysfunction, such as cancer, neurodegenerative disease, and cardiovascular disease. Challenges and suggestions for further investigations of NM-mediated autophagy are proposed with the purpose to improve their biosafety evaluation and facilitate their wide application. Databases such as PubMed and Web of Science were utilized to search for relevant literature, which included all published, Epub ahead of print, in-process, and non-indexed citations. In this review, we focus on the dual effect of NM-mediated autophagy in the biomedical field. It has become a trend to use the benefits of NM-mediated autophagy to treat clinical diseases such as cancer and neurodegenerative diseases. Understanding the regulatory mechanism of NM-mediated autophagy in biomedicine is also helpful for reducing the toxic effects of NMs as much as possible.

中文翻译:

纳米材料介导的自噬:生物医学中的危害与健康共存

纳米材料(NMs)的广泛生物医学应用由于其独特的理化特性而导致人体暴露的风险增加。自噬对调节机体的生理或病理活动非常重要,据报道在体内和体外,自噬在NM驱动的生物学效应中均起着关键作用。NM介导的自噬在生物​​医学中并存的危害和健康益处是不可忽略的,需要我们特别关注。我们收集了有关NM介导的自噬在体内和体外的毒性作用的研究。通常,NMs可通过不同的给药途径传递到动物模型中,或通过不同的摄取途径被细胞内化,从而在组织,器官,细胞和细胞器中造成不同程度的损伤,最终沉积在体内或从体内排出。此外,NMs的其他生物学作用,例如氧化应激,炎症,坏死性坏死病,焦斑病和肥大病,已与自噬结合在一起并共同调节身体活动。因此,我们强调了NM介导的自噬是一把双刃剑,可用于治疗与自噬功能障碍相关的某些疾病,例如癌症,神经退行性疾病和心血管疾病。提出了进一步研究NM介导的自噬的挑战和建议,目的是改善其生物安全性评估并促进其广泛应用。利用诸如PubMed和Web of Science之类的数据库来搜索相关文献,其中包括所有已出版的,出版前的Epub,进行中的,和非索引引用。在这篇综述中,我们专注于NM介导的自噬在生物​​医学领域的双重作用。利用NM介导的自噬的优势来治疗诸如癌症和神经退行性疾病的临床疾病已成为一种趋势。了解NM介导的自噬在生物​​医学中的调节机制也有助于尽可能减少NM的毒性作用。
更新日期:2020-10-17
down
wechat
bug