Recent studies underline a potential role of autoimmune and genetic disturbances in this disorder pathogenesis. Variants in genes related to inflammatory processes may possibly predispose to chronic spontaneous urticaria (CSU) occurrence. The objective of this study was to search for an association of Il1 genes polymorphisms with the pathogenesis of CSU. The examined group consisted of 153 unrelated chronic spontaneous autoreactive urticaria patients. The control group consisted of 104 unrelated healthy volunteers. In all studied subjects, IL1 rs1304037 and rs180058 polymorphisms were examined. The Urticaria Activity Score was used to assess disease intensity. The age of disease onset was also analyzed. Statistically significantly higher prevalence of Il1 rs1304037 TT genotype and T allele among CSU was proved. Similarly, the prevalence of Il1 rs1800587 GG genotype and G allele was statistically significantly higher in the CSU group. Haplotype combination rs1304037C/rs1800587G was statistically significantly more frequent in CSU, whereas rs1304037C/rs1800587A revealed statistically significantly less frequent occurrence in CSU. We did not observe any relationship between Il1 genotypes and the disease severity or age of disease onset. We are the first to suggest a significant role of IL1 gene polymorphisms in the susceptibility to CSU. This observation may lead to a better pathogenesis understanding and more effective treatment. We recommend further studies on other polymorphisms in chronic urticaria to analyze the role of the genetic mechanisms in the pathogenesis of this disorder.

中文翻译：

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白细胞介素1基因多态性可能参与慢性自发性自身反应性荨麻疹的发病机制

最近的研究强调了自身免疫和遗传紊乱在这种疾病发病机制中的潜在作用。与炎症过程相关的基因变异可能导致慢性自发性荨麻疹 (CSU) 的发生。本研究的目的是寻找Il1基因多态性与 CSU 发病机制的关联。检查组由 153 名无关的慢性自发性自身反应性荨麻疹患者组成。对照组由 104 名无关的健康志愿者组成。在所有研究对象中，检查了IL1 rs1304037 和 rs180058 多态性。荨麻疹活动评分用于评估疾病强度。还分析了发病年龄。统计学上显着更高的Il1患病率rs1304037 TT基因型和T等位基因在CSU中得到证实。同样，CSU 组中Il1 rs1800587 GG 基因型和 G 等位基因的流行率在统计学上显着更高。单倍型组合 rs1304037C/rs1800587G 在 CSU 中的频率在统计学上显着更高，而 rs1304037C/rs1800587A 在 CSU 中的发生频率在统计学上显着更低。我们没有观察到Il1基因型与疾病严重程度或发病年龄之间的任何关系。我们是第一个提出IL1具有重要作用的人CSU 易感性的基因多态性。这一观察结果可能会导致更好的发病机制理解和更有效的治疗。我们建议进一步研究慢性荨麻疹的其他多态性，以分析遗传机制在该病发病机制中的作用。