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Anatomical identification of the neuroendocrine system in the Nothobranchius furzeri brain
bioRxiv - Cell Biology Pub Date : 2020-10-16 , DOI: 10.1101/2020.10.15.342014
Eunjeong Do , Yumi Kim

The hypophysis functions as a central gland of the neuroendocrine system for regulating fundamental body physiology. Upon aging, several hormones produced by the endocrine system are dramatically altered. Recently, Nothobranchius furzeri (the turquoise killifish) has become a popular model for aging studies because of its short lifespan and highly conserved aging phenotypes. However, the anatomical details of the major neuroendocrine system of the killifish have not been investigated so far. In this study, we have identified the pituitary and pineal glands of the turquoise killifish, which are critical components of the brain endocrine system. These two neuroendocrine glands were weakly attached to the main body of the killifish brain. The pineal gland was located on the dorsal part of the brain, while the pituitary gland was located on the ventral part. Brain sections containing pineal and pituitary glands were performed and revealed that cells in both the pituitary and pineal glands are densely placed than any other regions of brain. Further, three-dimensional images both in pineal and pituitary glands were uncovered their distinctive cellular arrangements. Vasopressin intestinal peptide (VIP) was strongly expressed in the neurohypophysis of the pituitary gland. Glial cells were found inside the pineal gland, while astrocytes covered the outside. These findings illustrate basic features of the neuroendocrine system of Nothobranchius furzeri.

中文翻译:

弗氏诺氏裂脑的神经内分泌系统的解剖学鉴定

脑下垂体是神经内分泌系统的中央腺体,用于调节身体的基本生理。随着年龄的增长,内分泌系统产生的几种激素会发生巨大变化。近来,由于其寿命短和高度保守的衰老表型,Nothobranchius furzeri(绿松石i鱼)已成为衰老研究的流行模型。但是,到目前为止,还没有研究过金鱼的主要神经内分泌系统的解剖学细节。在这项研究中,我们确定了绿松石kill鱼的垂体和松果体,它们是大脑内分泌系统的关键组成部分。这两个神经内分泌腺体微弱地附着在比目鱼脑的主体上。松果体位于大脑的背侧,垂体位于腹侧。进行了包含松果体和垂体腺的脑切片,发现脑垂体和松果体中的细胞都比大脑的其他任何区域都密集。此外,在松果体和垂体中的三维图像都发现了其独特的细胞排列。加压素肠肽(VIP)在垂体的神经垂体中强烈表达。在松果体内部发现了胶质细胞,而星形胶质细胞则覆盖了外部。这些发现说明了柔支夜蛾的神经内分泌系统的基本特征。松果体和垂体的三维图像都被发现了其独特的细胞排列。加压素肠肽(VIP)在垂体的神经垂体中强烈表达。在松果体内部发现了胶质细胞,而星形胶质细胞覆盖了外部。这些发现说明了柔支夜蛾的神经内分泌系统的基本特征。松果体和垂体的三维图像都被发现了其独特的细胞排列。加压素肠肽(VIP)在垂体的神经垂体中强烈表达。在松果体内部发现了胶质细胞,而星形胶质细胞则覆盖了外部。这些发现说明了柔支夜蛾的神经内分泌系统的基本特征。
更新日期:2020-10-17
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