The biochemical integrity of the brain is paramount to the function of the central nervous system, and oxidative stress is a key contributor to cerebral biochemical impairment. Oxidative stress, which occurs when an imbalance arises between the production of reactive oxygen species (ROS) and the efficacy of the antioxidant defense mechanism, is believed to play a role in the pathophysiology of various brain disorders. One such disorder, schizophrenia, not only causes lifelong disability but also induces severe emotional distress; however, because of its onset in early adolescence or adulthood and its progressive development, consuming natural antioxidant products may help regulate the pathogenesis of schizophrenia. Therefore, elucidating the functions of ROS and dietary antioxidants in the pathogenesis of schizophrenia could help formulate improved therapeutic strategies for its prevention and treatment. This review focuses specifically on the roles of ROS and oxidative damage in the pathophysiology of schizophrenia, as well as the effects of nutrition, antipsychotic use, cognitive therapies, and quality of life on patients with schizophrenia. By improving our understanding of the effects of various nutrients on schizophrenia, it may become possible to develop nutritional strategies and supplements to treat the disorder, alleviate its symptoms, and facilitate long-term recovery.

中文翻译：

---

精神分裂症发病机理中活性氧介导的损伤的调节

大脑的生化完整性对中枢神经系统的功能至关重要，氧化应激是导致大脑生化损伤的关键因素。人们认为，当活性氧（ROS）的产生与抗氧化防御机制的功效之间出现不平衡时，就会发生氧化应激，这种氧化应激在各种脑部疾病的病理生理学中起着重要作用。一种这样的疾病，精神分裂症，不仅会导致终身残疾，还会引起严重的情绪困扰。然而，由于其在青春期或成年初期发作并逐渐发展，食用天然抗氧化剂产品可能有助于调节精神分裂症的发病机理。因此，阐明ROS和饮食抗氧化剂在精神分裂症发病机理中的作用可有助于制定改进的预防和治疗策略。这篇综述特别关注ROS和氧化损伤在精神分裂症的病理生理中的作用，以及营养，抗精神病药物的使用，认知疗法和生活质量对精神分裂症患者的影响。通过增进我们对各种营养素对精神分裂症影响的理解，可能有可能制定营养策略和补充剂来治疗该疾病，减轻其症状并促进长期康复。以及营养，抗精神病药的使用，认知疗法和生活质量对精神分裂症患者的影响。通过增进我们对各种营养素对精神分裂症影响的理解，可能有可能制定营养策略和补充剂来治疗该疾病，减轻其症状并促进长期康复。以及营养，抗精神病药的使用，认知疗法和生活质量对精神分裂症患者的影响。通过增进我们对各种营养素对精神分裂症影响的理解，可能有可能制定营养策略和补充剂来治疗该疾病，减轻其症状并促进长期康复。