The widespread and uncontrollable emergence of antibiotic-resistant bacteria, especially methicillin-resistant Staphylococcus aureus, has promoted a wave of efforts to discover a new generation of antibiotics that prevent or treat bacterial infections neither as bactericides nor bacteriostats. Due to its crucial role in virulence and its nonessentiality in bacterial survival, sortase A has been considered as a great target for new antibiotics. Sortase A inhibitors have emerged as promising alternative antivirulence agents against bacteria. Herein, the structural and preparative aspects of some small synthetic organic compounds that block the pathogenic action of sortase A have been described.

中文翻译：

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小分子强效金黄色葡萄球菌Sortase A抑制剂的设计与合成

抗生素耐药性细菌，尤其是耐甲氧西林金黄色葡萄球菌的广泛出现和不可控制的出现，推动了人们努力寻找一种新一代的抗生素，这些抗生素既可以预防也不能治疗细菌感染，而不能作为杀菌剂或抑菌剂。由于其在毒力中的关键作用及其在细菌存活中的重要性，分选酶A被认为是新抗生素的重要靶标。Sortase A抑制剂已成为有前途的替代细菌抗毒剂。在此，已经描述了一些阻止分选酶A的致病作用的小的合成有机化合物的结构和制备方面。