Resistance to anti-tuberculosis (anti-TB) antibiotics is a major public health concern for many high-TB burden countries in Asia, including Bangladesh. Therefore, to represent the overall drug-resistance pattern against TB in Bangladesh, a systematic review and meta-analysis was conducted. Databases such as PubMed, Scopus, and Google Scholar were searched to identify studies related to antibiotic-resistant TB. A total of 24 studies covering 13,336 patients with TB were secured and included. The random-effects model was used to calculate the summary estimates. The pooled prevalence of any, mono, multi, poly, and extensive anti-TB antibiotic-resistances were 45.3% [95% CI: 33.5–57.1], 14.3% [95% CI: 11.4–17.2], 22.2% [95% CI: 18.8–25.7], 7.7% [95% CI: 5.6–9.7], and 0.3% [95% CI: 0.0–1.0], respectively. Among any first and second-line anti-TB drugs, isoniazid (35.0%) and cycloserine (44.6%) resistances were the highest, followed by ethambutol (16.2%) and gatifloxacin (0.2%). Any, multi, and poly drug-resistances were higher in retreatment cases compared to the newly diagnosed cases, although mono drug-resistance tended to be higher in newly diagnosed cases (15.7%) than that in retreatment cases (12.5%). The majority (82.6%) of the included studies were of high quality, with most not exhibiting publication bias. Sensitivity analyses confirmed that all outcomes are robust and reliable. It is concluded that resistance to anti-TB drugs in Bangladesh is rampant and fast growing. Therefore, the implementation of a nationwide surveillance system to detect suspected and drug-resistant TB cases, as well as to ensure a more encompassing treatment management by national TB control program, is highly recommended.

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孟加拉国抗药性肺结核的患病率：系统评价和荟萃分析

对于包括孟加拉国在内的亚洲许多高结核病负担国家来说，抗结核（抗结核）抗生素的耐药性是主要的公共卫生问题。因此，为了代表孟加拉国对结核病的总体耐药模式，进行了系统的回顾和荟萃分析。搜索诸如PubMed，Scopus和Google Scholar之类的数据库，以确定与抗生素抗药性结核相关的研究。总共确保并纳入了涵盖13336例结核病患者的24项研究。随机效应模型用于计算汇总估算。任何，单药，多药，多药和广泛抗结核抗生素耐药性的合并患病率分别为45.3％[95％CI：33.5-57.1]，14.3％[95％CI：11.4-17.2]，22.2％[95％ CI：18.8–25.7]，7.7％[95％CI：5.6–9.7]和0.3％[95％CI：0.0–1.0]。在任何一线和二线抗结核药物中，异烟肼（35.0％）和环丝氨酸（44.6％）的耐药性最高，其次是乙胺丁醇（16.2％）和加替沙星（0.2％）。与新诊断的病例相比，再治疗病例中的任何，多重和多药耐药性更高，尽管在新诊断的病例中单药耐药性（15.7％）倾向于高于再治疗病例（12.5％）。纳入研究的大多数（82.6％）是高质量的，大多数没有表现出偏倚。敏感性分析证实，所有结果都是可靠和可靠的。结论是，孟加拉国对抗结核药物的耐药性猖and并且正在迅速增长。因此，实施全国性的监视系统以发现可疑和耐药的结核病病例，并通过国家结核病控制计划确保更全面的治疗管理，