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Catalytic Asymmetric Reductive Alkylation of Enamines to Chiral Aliphatic Amines
ChemRxiv Pub Date : 2020-10-16
Jia-Wang Wang, Yan Li, Wan Nie, Zhe Chang, Zi-An Yu, Yi-Fan Zhao, Xi Lu, Yao Fu

Herein, we report a mild and general nickel-catalysed asymmetric reductive alkylation to effectively convert enamines—a class of important yet underexploited feedstock chemicals—into drug-like α-branched chiral amines and derivatives. This reaction involves the regio- and stereoselective hydrometallation of an enamine to generate a catalytic amount of enantioenriched alkylnickel intermediate, followed by C–C bond formation via alkyl electrophiles.

中文翻译:

烯胺催化不对称还原烷基化为手性脂肪胺

本文中,我们报道了一种温和且一般的镍催化不对称还原烷基化作用,可将烯胺(一类重要但尚未充分利用的原料化学品)有效地转化为药物样的α支化手性胺和衍生物。该反应涉及烯胺的区域和立体选择性加氢金属化反应,以产生催化量的对映体富集的烷基镍中间体,然后通过烷基亲电试剂形成CC键。
更新日期:2020-10-17
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