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Increased RNA editing in maternal immune activation model of neurodevelopmental disease
Nature Communications ( IF 16.6 ) Pub Date : 2020-10-16 , DOI: 10.1038/s41467-020-19048-6
Hadas Tsivion-Visbord , Eli Kopel , Ariel Feiglin , Tamar Sofer , Ran Barzilay , Tali Ben-Zur , Orly Yaron , Daniel Offen , Erez Y. Levanon

The etiology of major neurodevelopmental disorders such as schizophrenia and autism is unclear, with evidence supporting a combination of genetic factors and environmental insults, including viral infection during pregnancy. Here we utilized a mouse model of maternal immune activation (MIA) with the viral mimic PolyI:C infection during early gestation. We investigated the transcriptional changes in the brains of mouse fetuses following MIA during the prenatal period, and evaluated the behavioral and biochemical changes in the adult brain. The results reveal an increase in RNA editing levels and dysregulation in brain development-related gene pathways in the fetal brains of MIA mice. These MIA-induced brain editing changes are not observed in adulthood, although MIA-induced behavioral deficits are observed. Taken together, our findings suggest that MIA induces transient dysregulation of RNA editing at a critical time in brain development.



中文翻译:

在神经发育疾病的母体免疫激活模型中增加RNA编辑

尚不清楚主要的神经发育障碍(如精神分裂症和自闭症)的病因,证据支持遗传因素和环境损害相结合,包括怀孕期间的病毒感染。在这里,我们利用了妊娠早期病毒模拟的PolyI:C感染的母体免疫激活(MIA)小鼠模型。我们调查了产前时期MIA之后小鼠胎儿大脑中的转录变化,并评估了成年大脑的行为和生化变化。结果显示,MIA小鼠胎儿大脑中与大脑发育相关的基因途径中的RNA编辑水平和失调增加。尽管观察到MIA引起的行为缺陷,但在成年期未观察到这些MIA引起的大脑编辑变化。在一起

更新日期:2020-10-17
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