ABSTRACT

Characteristics of the chronotypes of patients with gastrointestinal disease are unknown. We evaluated chronotypes of patients with upper gastrointestinal diseases with the Munich ChronoType Questionnaire (MCTQ). A total of 2027 subjects from 29 institutions in Japan who had undergone esophagogastroduodenoscopy were asked to answer the MCTQ. The subjects’ chronotypes were divided into three groups (early, intermediate, and late chronotype) using the sleep-corrected mid-point of sleep on free days (MSF_SC) values. According to their endoscopic diagnosis and abdominal symptoms, the subjects were divided into the reflux esophagitis (RE) group, gastroduodenal ulcer (GDU) group, upper gastrointestinal carcinoma (CA) group, functional dyspepsia (FD) group, non-FD group, and control group. In total, 1128 subjects were eligible for the analysis. The MSF_SC (average ± standard deviation, clock hours, h) of each disease group was as follows: control group: 02.51 ± 1.22, non-FD group: 02.69 ± 1.14, FD group: 02.91 ± 1.19, RE group: 02.58 ± 1.05, GDU group: 02.47 ± 1.31, and CA group: 02.11 ± 1.08 h. Compared to the control group, the rate of late chronotype of the FD group significantly increased to 33.3%, whereas that of early chronotype of the CA group significantly increased to 38.3% (P = .0177 and 0.0036, respectively). In both the FD and CA groups, chronotype was the independent factor related to the diseases. The adjusted odds ratio of late chronotype to early chronotype was 3.01 [95% CI, 1.23–7.35] in the FD group and 0.44 [95% CI, 0.23–0.85] in the CA group. In conclusion, late chronotype was common in patients with FD, and early chronotype was common in patients with upper gastrointestinal carcinoma.

摘要

胃肠道疾病患者的时间型特征尚不清楚。我们使用慕尼黑时间类型问卷 (MCTQ) 评估了上消化道疾病患者的时间类型。来自日本 29 个机构的 2027 名接受过食管胃十二指肠镜检查的受试者被要求回答 MCTQ。使用自由日睡眠校正中点（MSF _SC) 值。根据内镜诊断和腹部症状，将受试者分为反流性食管炎（RE）组、胃十二指肠溃疡（GDU）组、上消化道癌（CA）组、功能性消化不良（FD）组、非FD组和控制组。总共有 1128 名受试者符合分析条件。各疾病组的MSF _SC（平均值±标准差，时钟小时数，h）如下：对照组：02.51±1.22，非FD组：02.69±1.14，FD组：02.91±1.19，RE组：02.58± 1.05，GDU组：02.47±1.31，CA组：02.11±1.08h。与对照组相比，FD组晚型发生率显着上升至33.3%，而CA组早型发生率显着上升至38.3%（P= .0177 和 0.0036，分别）。在 FD 和 CA 组中，睡眠类型是与疾病相关的独立因素。在 FD 组中，晚型与早型的调整优势比为 3.01 [95% CI，1.23-7.35]，CA 组为 0.44 [95% CI，0.23-0.85]。综上所述，FD 患者中晚型多见，上消化道癌患者中早型多见。