Abstract

Review of the literature cited in documentation of hazard assessments of PAH-involved industries and PAH-containing materials combined with the results of systematic reviews and meta-analyses of the many occupational exposure studies of PAH-involved industries indicates that authoritative review bodies should revisit hazard assessments and thoroughly update the assessments and documentation for PAH-involved occupations using quantitative methods. Current hazard classifications rely heavily on case reports and studies of uncertain or questionable quality with little documentation of review processes. The classification process should adopt transparent, systematic methods beginning with establishing criteria for inclusion of information in the review and should also assess potential biases. The methods of systematic review and meta-analysis should be adopted when data of sufficient quantity and quality are available. Published systematic reviews of occupational exposure studies conducted in PAH-involved industries demonstrate the feasibility of quantitative methods for assessing exposures to PAH-containing materials, and indicate that current assessments overstate associations with skin, lung, and other types of cancer. The review should include consideration of the ways quantitative measures may be useful in developing hazard classifications.

摘要

对涉及 PAH 的行业和含 PAH 材料的危害评估文件中引用的文献进行回顾，结合对涉及 PAH 行业的许多职业暴露研究的系统回顾和荟萃分析的结果，表明权威审查机构应重新审视危害使用定量方法对涉及 PAH 的职业的评估和文件进行彻底更新。当前的危害分类严重依赖于案例报告和质量不确定或有问题的研究，几乎没有审查过程的文件。分类过程应采用透明、系统的方法，从建立评价纳入信息的标准开始，还应评估潜在的偏差。并指出当前的评估夸大了与皮肤癌、肺癌和其他类型癌症的关联。审查应包括考虑量化措施可能有助于制定危害分类的方式。并指出当前的评估夸大了与皮肤癌、肺癌和其他类型癌症的关联。审查应包括考虑量化措施可能有助于制定危害分类的方式。