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Development and application of an outcome-centric approach for conducting overviews of reviews
Applied Physiology, Nutrition, and Metabolism ( IF 3.4 ) Pub Date : 2020-10-15 , DOI: 10.1139/apnm-2020-0564
Michelle E Kho 1 , Veronica J Poitras 2 , Ian Janssen 3, 4 , Jean-Philippe Chaput 5 , Travis J Saunders 6 , Lora M Giangregorio 7, 8 , Jennifer R Tomasone 3 , Amanda Ross-White 9 , Robert Ross 3
Affiliation  

Applied Physiology, Nutrition, and Metabolism, Volume 45, Issue 10 (Suppl. 2), Page S151-S164, October 2020.
There are gaps in current guidance concerning how to conduct overviews of systematic reviews in an outcome-centric manner. Herein we summarize the methods and lessons learned from conducting 4 outcome-centric overviews to help inform the Canadian 24-Hour Movement Guidelines for Adults aged 18–64 years and Adults aged 65 years or older on the topics of resistance training, balance and functional training, sedentary behaviour, sleep duration. We defined “critical” and “important” outcomes a priori. We used AMSTAR 2 to assess review quality and sought 1 systematic review per outcome. If multiple reviews were required to address subgroups for an outcome, we calculated the corrected covered area (CCA) to quantify overlap. We report our methodology in a PRISMA table. Across the 4 overviews, authors reviewed 1110 full texts; 45 were retained (low to high quality per AMSTAR 2), representing 950 primary studies, enrolling over 5 385 500 participants. Of 46 outcomes, we identified data for 35. Nineteen outcomes required >1 review (CCA range: 0% to 71.4%). Our outcome-centric overviews addressed unique aspects of overviews, including selection and quality assessment of included reviews, and overlap. Lessons learned included consistent application of methodological principles to minimize bias and optimize reporting transparency. Novelty Overviews of reviews synthesize systematic reviews in a rigorous and transparent manner. Outcome-centric systematic reviews assess the quality of evidence for primary studies contributing to an outcome. This manuscript describes the development and application of extending the concept of outcome-centric systematic reviews to the design and conduct of outcome-centric overviews.


中文翻译:

开发和应用以结果为中心的方法来进行综述

应用生理学、营养和代谢,第 45 卷,第 10 期(增刊 2),第 S151-S164 页,2020 年 10 月。
目前关于如何以结果为中心的方式进行系统评价概述的指南存在差距。在此,我们总结了从进行 4 个以结果为中心的概述中获得的方法和经验教训,以帮助告知加拿大 18-64 岁成人和 65 岁或以上成人的 24 小时运动指南,涉及阻力训练、平衡和功能训练的主题,久坐行为,睡眠时间。我们先验地定义了“关键”和“重要”结果。我们使用 AMSTAR 2 来评估评价质量,并为每个结果寻求 1 次系统评价。如果需要多次审查来解决某个结果的亚组问题,我们会计算校正覆盖面积 (CCA) 以量化重叠。我们在 PRISMA 表中报告了我们的方法。在 4 个综述中,作者审阅了 1110 篇全文;保留了 45 项(根据 AMSTAR 2 从低到高质量),代表 950 项主要研究,招募了超过 5 385 500 名参与者。在 46 个结果中,我们确定了 35 个的数据。 19 个结果需要 >1 次审查(CCA 范围:0% 到 71.4%)。我们以结果为中心的概述解决了概述的独特方面,包括所包含评论的选择和质量评估以及重叠。经验教训包括一致应用方法论原则,以尽量减少偏见和优化报告透明度。综述的新颖性概述以严格和透明的方式综合系统综述。以结果为中心的系统评价评估有助于结果的主要研究的证据质量。
更新日期:2020-10-17
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