Bee venom (apitoxin) is a complex mixture of enzymes, peptides, amines, and other chemicals that presents diverse pharmaceutical activities. Melittin, a small peptide with 2.84 kDa, represents about 50% of this venom, on a dry basis. However, allergenic compounds, such as phospholipase A2 and hyaluronidase (enzymes with a molecular weight of 19 and 38 kDa, respectively), impair the direct use of apitoxin. The membrane separation process can be considered a potential approach for the fractionation of those components. Therefore, the cross‐flow ultrafiltration with a 10 kDa regenerated cellulose membrane was used to separate melittin from apitoxin, leading to lower fouling in the membrane.

中文翻译：

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通过错流超滤工艺有效去除磷脂酶A2去除阿维毒素的蜂毒素回收

蜂毒（蜂毒素）是酶，肽，胺和其他化学物质的复杂混合物，具有多种药物活性。蜂毒素（Melittin）是一种具有2.84 kDa的小肽，以干基计约占该毒液的50％。但是，变应原性化合物，例如磷脂酶A2和透明质酸酶（分别具有19和38 kDa的分子量的酶）会损害直接使用Apitoxin的作用。膜分离过程可以被认为是分离这些组分的潜在方法。因此，采用具有10 kDa再生纤维素膜的错流超滤技术可将蜂毒肽与阿托帕辛分开，从而降低了膜的结垢率。