Autophagy is an intracellular degradation system widely conserved among various species. Autophagy is induced by the depletion of various nutrients, and this degradation mechanism is essential for adaptation to such conditions. In this study, we demonstrated that sulfur depletion induces autophagy in the fission yeast Schizosaccharomyces pombe. Based on the finding that autophagy induced by sulfur depletion was completely abolished in a mutant in which the ecl1, ecl2 and ecl3 genes were deleted (Δecls), we report that these three genes are essential for the induction of autophagy by sulfur depletion. Furthermore, autophagy‐defective mutant cells exhibited poor growth and short lifespan (compared with wild‐type cells) under the sulfur‐depleted condition. These results indicated that the mechanism of autophagy is necessary for the appropriate adaptation to sulfur depletion.

中文翻译：

---

硫耗竭通过裂变酵母中的Ecl1家族基因诱导自噬

自噬是一种在各种物种中广泛保守的细胞内降解系统。自噬是由于各种营养素的消耗而引起的，这种降解机制对于适应这种条件至关重要。在这项研究中，我们证明了硫耗竭诱导裂殖酵母粟酒裂殖酵母中的自噬。根据这一发现，在缺失了ecl1，ecl2和ecl3基因的突变体中，硫耗尽引起的自噬被完全消除（Δecls），我们报告这三个基因对于通过硫耗竭诱导自噬至关重要。此外，在缺硫条件下，自噬缺陷型突变细胞表现出较差的生长和较短的寿命（与野生型细胞相比）。这些结果表明自噬机理对于适当适应硫耗竭是必需的。